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Relationship between serum osteocalcin levels and carotid intima-media thickness in Chinese postmenopausal women

Yang, Rong MD1; Ma, Xiaojing MD1; Dou, Jianxin MD1; Wang, Feifei MD1; Luo, Yuqi MD1; Li, Diancheng MD2; Zhu, Jiaan MD, PhD2; Bao, Yuqian MD1; Jia, Weiping MD, PhD1

Menopause:
doi: 10.1097/GME.0b013e31828aa32d
Original Study
Abstract

Objective: Serum osteocalcin has been shown to be closely related to metabolic risk factors. Therefore, the aim of our study was to evaluate the association between serum osteocalcin levels and subclinical atherosclerosis in Chinese postmenopausal women.

Methods: A total of 1,319 postmenopausal women (age range, 41-78 y) without any history of cardiovascular disease or carotid plaque were analyzed. Electrochemiluminescence immunoassay was used to measure total serum osteocalcin levels. B-mode ultrasound measurement of carotid intima-media thickness (C-IMT) was used to evaluate subclinical atherosclerosis. Participants within the upper quartile of C-IMT measurements (≥0.65 mm) were classified as having increased C-IMT in the present study. C-IMT association with metabolic parameters was assessed by Spearman correlation analysis, whereas that with serum osteocalcin was assessed by multiple stepwise regression adjusted for potential confounders.

Results: The overall median (interquartile range) level of osteocalcin was 20.51 (16.71-24.98) ng/mL, and that of C-IMT was 0.60 (0.55-0.65) mm. Four hundred sixteen (31.5%) participants had increased C-IMT. Participants with increased C-IMT had significantly lower serum osteocalcin levels than those who had C-IMT lower than 0.65 mm (19.77 [16.17-24.52] vs 20.84 [16.92-25.39] ng/mL, P = 0.01). Serum osteocalcin level was significantly and negatively correlated with C-IMT (r = −0.107, P < 0.01) and was identified as an independent factor that significantly influenced C-IMT (standardized β = −0.117, P < 0.01).

Conclusions: Serum osteocalcin level is negatively associated with subclinical atherosclerosis in Chinese postmenopausal women.

Author Information

From the 1Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China; and 2Department of Ultrasound, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Institute of Ultrasound in Medicine, Shanghai, China.

Received November 29, 2012; revised and accepted January 24, 2013.

R.Y. and X.M. contributed equally to this work.

Funding/support: This work was funded by the 973 Program of China (2013CB530606), the National Natural Science Foundation of China (81170788), the National Key Technology R&D Program of China (2012BAI02B03), and the Special Scientific Research Fund of Medicine Sanitary (201002002).

Financial disclosure/conflicts of interest: None reported.

Address correspondence to: Yuqian Bao, MD, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai 200233, China. E-mail: byq522@163.com

© 2013 by The North American Menopause Society.