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doi: 10.1097/GME.0b013e3182a7c57b
Clinical Corner: Clinical Article

Menopause practitioner perspective on the American Society of Bone and Mineral Research Task Force report on atypical femoral fracture

Ettinger, Bruce MD1; Stuenkel, Cynthia A. MD2; Schnatz, Peter F. DO3

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Clinical Scenario: One of your patients, a 59-year-old postmenopausal Asian woman (menopause, age 52), took hormone therapy for about one year for her menopause symptoms. When she was 54, her mother (age 80) suffered a hip fracture, and she requested a bone density test at her next gynecology visit. The t-score results were spine, −1.1; total hip, −1.8; and femoral neck, −2.1, all in the osteopenic range. After some discussion, she was started on alendronate 70 mg once a week, together with calcium and vitamin D. Follow-up dual-energy x-ray absorptiometry testing after 2 and 5 years of therapy showed increases in bone mineral density, resulting in t-score improvements of about 0.3 to 0.5 units (spine was now normal; femoral neck was −1.8). The Fracture Risk Assessment Tool estimated her 10-year risk of hip fracture to be 0.4% and her 10-year risk of any of 4 major osteoporotic fractures to be 7.5%. During her most recent gynecology visit, she expressed concern about unusual femoral fractures being linked to long-term use of alendronate. She asks if there is reason for her to stop using this drug.

© 2013 by The North American Menopause Society.


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