Skip Navigation LinksHome > October 2013 - Volume 20 - Issue 10 > Even low physical activity levels improve vascular function...
doi: 10.1097/GME.0b013e31828501c9
Original Study

Even low physical activity levels improve vascular function in overweight and obese postmenopausal women

Merino, Jordi MD1,2; Ferré, Raimon PhD1,2; Girona, Josefa PhD1,2; Aguas, Dolors MD3; Cabré, Anna PhD1,2; Plana, Núria PhD1,2; Vinuesa, Angels MD4,5; Ibarretxe, Daiana MD1,2; Basora, Josep PhD4,5; Buixadera, Carme MD1,2; Masana, Lluís PhD1,2

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Objective: Some individuals with cardiovascular risk are unable to achieve even the lower internationally recommended level of physical activity (PA). We aimed to study the impact of a lower-than-advised level of PA on small artery vascular function and oxidative stress in overweight and obese postmenopausal women.

Methods: Forty-seven overweight and obese postmenopausal women completed a 4-month program of 1-hour low-intensity PA for 2 days per week. Before and after the intervention, PA level (metabolic equivalent tasks/h/wk), endogenous antioxidant status (superoxide dismutase and erythrocyte lysate and glutathione peroxidase erythrocyte lysate concentrations, superoxide dismutase plasma and glutathione peroxidase plasma [GPXa] activities, and oxidized low-density lipoprotein), asymmetrical dimethylarginine concentrations, endothelial function by small artery reactive hyperemia index (saRHI), and resting heart rate (RHR) were assessed.

Results: After the intervention, a significant increase in GPXa and decreases in asymmetrical dimethylarginine concentrations and RHR (P < 0.001 for all) were observed. Increases in PA were positively associated with increases in saRHI (r = 0.330, P = 0.027) and GPXa (r = 0.299, P = 0.05) and a decrease in RHR (r = −0.297, P = 0.047). Multivariate analyses showed that the independent predictors of saRHI improvement were an increase in PA (β = 2.63; 95% CI, 1.24-4.19; P = 0.019), a decrease in RHR (β = 1.96; 95% CI, 1.01-5.03; P = 0.048), and an increase in GPXa (β = 2.64; 95% CI, 1.18-5.08; P = 0.021).

Conclusions: Even low-intensity PA improves antioxidant capacity, RHR, and saRHI in postmenopausal women. Advising postmenopausal women to increase their PA at any level seems warranted based on our preliminary and hypothesis-generating data.

© 2013 by The North American Menopause Society.


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