Home Current Issue Previous Issues Published Ahead-of-Print Collections For Authors Journal Info
Skip Navigation LinksHome > October 2013 - Volume 20 - Issue 10 > Even low physical activity levels improve vascular function...
Menopause:
doi: 10.1097/GME.0b013e31828501c9
Original Study

Even low physical activity levels improve vascular function in overweight and obese postmenopausal women

Merino, Jordi MD1,2; Ferré, Raimon PhD1,2; Girona, Josefa PhD1,2; Aguas, Dolors MD3; Cabré, Anna PhD1,2; Plana, Núria PhD1,2; Vinuesa, Angels MD4,5; Ibarretxe, Daiana MD1,2; Basora, Josep PhD4,5; Buixadera, Carme MD1,2; Masana, Lluís PhD1,2

Collapse Box

Abstract

Objective

Some individuals with cardiovascular risk are unable to achieve even the lower internationally recommended level of physical activity (PA). We aimed to study the impact of a lower-than-advised level of PA on small artery vascular function and oxidative stress in overweight and obese postmenopausal women.

Methods

Forty-seven overweight and obese postmenopausal women completed a 4-month program of 1-hour low-intensity PA for 2 days per week. Before and after the intervention, PA level (metabolic equivalent tasks/h/wk), endogenous antioxidant status (superoxide dismutase and erythrocyte lysate and glutathione peroxidase erythrocyte lysate concentrations, superoxide dismutase plasma and glutathione peroxidase plasma [GPXa] activities, and oxidized low-density lipoprotein), asymmetrical dimethylarginine concentrations, endothelial function by small artery reactive hyperemia index (saRHI), and resting heart rate (RHR) were assessed.

Results

After the intervention, a significant increase in GPXa and decreases in asymmetrical dimethylarginine concentrations and RHR (P < 0.001 for all) were observed. Increases in PA were positively associated with increases in saRHI (r = 0.330, P = 0.027) and GPXa (r = 0.299, P = 0.05) and a decrease in RHR (r = −0.297, P = 0.047). Multivariate analyses showed that the independent predictors of saRHI improvement were an increase in PA (β = 2.63; 95% CI, 1.24-4.19; P = 0.019), a decrease in RHR (β = 1.96; 95% CI, 1.01-5.03; P = 0.048), and an increase in GPXa (β = 2.64; 95% CI, 1.18-5.08; P = 0.021).

Conclusions

Even low-intensity PA improves antioxidant capacity, RHR, and saRHI in postmenopausal women. Advising postmenopausal women to increase their PA at any level seems warranted based on our preliminary and hypothesis-generating data.

© 2013 by The North American Menopause Society

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.