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Management of symptomatic vulvovaginal atrophy: 2013 position statement of The North American Menopause Society

doi: 10.1097/GME.0b013e3182a122c2
Position Statement

Objective: To update and expand the previous position statement of The North American Menopause Society (NAMS) on the management of symptomatic vulvovaginal atrophy (VVA) in postmenopausal women.

Methods: NAMS searched PubMed for medical literature on VVA published since their 2007 position statement on the role of local vaginal estrogen for treatment of vaginal atrophy in postmenopausal women. A panel of acknowledged experts in the field of genitourinary health reviewed the literature to evaluate new evidence on local estrogen as well as on other management options available or in development for symptomatic VVA. The panel’s conclusions and recommendations were reviewed and approved by the NAMS Board of Trustees.

Results: Symptomatic VVA can significantly impair the quality of life (QOL) of postmenopausal women and may be underdiagnosed. In most cases, it can be managed successfully. A number of over-the-counter and government-approved prescription therapies available in the United States and Canada demonstrate effectiveness, depending on the severity of VVA symptoms. These include vaginal lubricants and moisturizers, vaginal estrogen, hormone therapy, and the selective estrogen-receptor modulator ospemifene (indicated for dyspareunia). Long-term studies on the endometrial safety of local estrogen and ospemifene are lacking. Changes in the vaginal microbiome have various effects on symptoms.

Conclusions: Clinicians can improve the sexual health and QOL of postmenopausal women by educating women about, diagnosing, and appropriately managing symptomatic VVA. Choice of therapy depends on the severity of symptoms, the effectiveness and safety of therapy for the individual patient, and patient preference. Estrogen therapy is the most effective treatment for moderate to severe symptoms, although a direct comparison of estrogen and ospemifene is not available. Nonhormonal therapies available without a prescription provide sufficient relief for most women with mild symptoms. When low-dose estrogen is administered locally, a progestogen is not indicated for women without a uterus and generally is not indicated for women with an intact uterus. However, endometrial safety has not been studied in clinical trials beyond 1 year. There are insufficient data to confirm the safety of local estrogen in women with breast cancer; management of VVA should take the woman’s needs and the recommendation of her oncologist into consideration. Research on the vaginal microbiome may lead to other therapies in the future.

Received June 17, 2013; revised and accepted June 17, 2013.

This position statement was developed by The North American Menopause Society (NAMS) 2013 Symptomatic Vulvovaginal Atrophy Advisory Panel consisting of representatives of the NAMS Board of Trustees and other experts in women’s health: Margery L.S. Gass, MD, NCMP, Chair; Gloria A. Bachman, MD; Steven R. Goldstein, MD, NCMP; Sheryl A. Kingsberg, PhD; James H. Liu, MD; Mark G. Martens, MD; Diane T. Pace, PhD, FNP, FAANP, NCMP; JoAnn V. Pinkerton, MD, NCMP; Jan L. Shifren, MD, NCMP. The Board of Trustees conducted independent review and revision and approved the position statement on June 7, 2013.

This position statement was made possible by donations to the NAMS Education & Research Fund. There was no commercial support.

Address correspondence to: The North American Menopause Society, 5900 Landerbrook Drive, Suite 390, Mayfield Heights, OH 44124. E-mail: info@menopause.org. Website: http://www.menopause.org.

© 2013 by The North American Menopause Society.