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Elevated intraocular pressure is associated with metabolic syndrome in postmenopausal women: the Korean National Health and Nutrition Examination Survey

Park, Byoung-Jin MD1; Park, Jin-Oh MD, PhD2; Kang, Hee-Taik MD3; Lee, Yong-Jae MD, MPH, PhD3

doi: 10.1097/GME.0b013e31827ce3c6
Original Articles

Objective: This study aimed to investigate the association between intraocular pressure and metabolic syndrome according to menopause status in nonglaucomatous Korean women.

Methods: We examined the relationship between intraocular pressure and metabolic syndrome in 4,524 nonglaucomatous Korean women (2,866 premenopausal women and 1,658 postmenopausal women) who participated in the 2008 Korean National Health and Nutrition Examination Survey. Multivariate linear regression analysis was used to assess the relationship between metabolic syndrome and intraocular pressure after adjusting for age, body mass index, smoking status, alcohol consumption, regular exercise, hypertension medication, and diabetes medication according to menopause status in women.

Results: The prevalence of metabolic syndrome was 5.4% for premenopausal women and 28.0% for postmenopausal women. The mean intraocular pressure gradually increased in accordance with the increasing number of components for metabolic syndrome in postmenopausal women (P = 0.002), but not in premenopausal women (P = 0.387). In multivariate regression analysis, intraocular pressure was significantly associated with metabolic syndrome in postmenopausal women (P = 0.015) after adjusting for confounding variables, but not in premenopausal women (P = 0.940).

Conclusions: Intraocular pressure was associated with metabolic syndrome in postmenopausal women, but not in premenopausal women. These findings suggest that intraocular pressure changes may be linked to metabolic syndrome in postmenopausal women.

In this cross-sectional study, elevated intraocular pressure is associated with metabolic syndrome in postmenopausal women, but not in premenopausal women. These findings suggest that intraocular pressure changes may be linked to metabolic syndrome in postmenopausal women.

From the 1Department of Family Medicine, CHA University College of Medicine, Seoul, Republic of Korea; and Departments of 2Orthopedic Surgery and 3Family Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

Received September 27, 2012; revised and accepted November 6, 2012.

Funding/support: None.

Financial disclosure/conflicts of interest: None reported.

Address correspondence to: Yong-Jae Lee, MD, MPH, PhD, Department of Family Medicine, Yonsei University College of Medicine, 225 Geumhakno, Yongin-si, Gyeonggi-do 449-930, Republic of Korea. E-mail: ukyjhome@yuhs.ac

© 2013 by The North American Menopause Society.