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Bone mineral density in postmenopausal Mexican-Mestizo women with normal body mass index, overweight, or obesity

Méndez, Juan Pablo MSc, MD1,2; Rojano-Mejía, David PhD, MD3; Pedraza, Javier MD2; Coral-Vázquez, Ramón Mauricio PhD, MSc4,5; Soriano, Ruth MPH2; García-García, Eduardo MD2; Aguirre-García, María del Carmen MD6; Coronel, Agustín VMD, MVZ5; Canto, Patricia MD, MsC, PhD5

doi: 10.1097/gme.0b013e318277694f
Original Articles

Objective: Obesity and osteoporosis are two important public health problems that greatly impact mortality and morbidity. Several similarities between these complex diseases have been identified. The aim of this study was to analyze if different body mass indexes (BMIs) are associated with variations in bone mineral density (BMD) among postmenopausal Mexican-Mestizo women with normal weight, overweight, or different degrees of obesity.

Methods: We studied 813 postmenopausal Mexican-Mestizo women. A structured questionnaire for risk factors was applied. Height and weight were used to calculate BMI, whereas BMD in the lumbar spine (LS) and total hip (TH) was measured by dual-energy x-ray absorptiometry. We used ANCOVA to examine the relationship between BMI and BMDs of the LS, TH, and femoral neck (FN), adjusting for confounding factors.

Results: Based on World Health Organization criteria, 15.13% of women had normal BMI, 39.11% were overweight, 25.96% had grade 1 obesity, 11.81% had grade 2 obesity, and 7.99% had grade 3 obesity. The higher the BMI, the higher was the BMD at the LS, TH, and FN. The greatest differences in size variations in BMD at these three sites were observed when comparing women with normal BMI versus women with grade 3 obesity.

Conclusions: A higher BMI is associated significantly and positively with a higher BMD at the LS, TH, and FN.

1Unidad de Investigación en Obesidad, Facultad de Medicina, Universidad Nacional Autónoma de México, México, DF, México; 2Clínica de Obesidad, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán,” México, DF, México; 3Unidad de Medicina Física y Rehabilitación, Región Centro, UMAE Lomas Verdes, Instituto Mexicano del Seguro Social, México, DF, México; 4Sección de Posgrado, Escuela Superior de Medicina, Instituto Politécnico Nacional, México, DF, México; 5División de Investigación Biomédica, Subdirección de Enseñanza e Investigación, Centro Médico Nacional 20 de Noviembre, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, México, DF, México; and 6Unidad de Medicina Familiar No. 20, Instituto Mexicano del Seguro Social, México, DF, México.

Received June 11, 2012; revised and accepted September 20, 2012.

Funding/support: This work was supported by grants from the Instituto de Ciencia y Tecnología del Distrito Federal (PICDS08-34) and the Consejo Nacional de Ciencia y Tecnología (grant SALUD-2009-113574).

Financial disclosure/conflicts of interest: None reported.

Address correspondence to: Patricia Canto, MD, MsC, PhD, División de Investigación Biomédica, Centro Médico Nacional 20 de Noviembre, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, San Lorenzo No. 502, Second Piso, Col. del Valle, Delegación Benito Juárez, CP 03100 México, DF, México. E-mail:

© 2013 by The North American Menopause Society.