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Menopause:
doi: 10.1097/gme.0b013e3182733921
Original Articles

Association between polymorphisms in renin-angiotensin system genes and primary ovarian insufficiency in Korean women

Jung, Yong Wook MD1; Jeon, Young Joo MS2,3; Park, Hye Mi MS2,3; Lee, Bo Eun BS2,3; Rah, HyungChul DVM, PhD2,3; Lee, Woo Sik MD, PhD4; Yoon, Tae Ki MD, PhD4; Kim, Nam Keun PhD2,3

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Abstract

Objective: The purpose of this study was to evaluate the relationship between angiotensin-converting enzyme (ACE; insertion/deletion), angiotensinogen (AGT M235T), and angiotensin II type 1 receptor (AT1R 1166A>C) and the prevalence of primary ovarian insufficiency (POI) in Korean women.

Methods: A total of 133 women with POI and 238 controls were genotyped for polymorphic sites in each gene using polymerase chain reaction–restriction fragment length polymorphism analysis.

Results: ACE ID and ID + II variants occurred more frequently in women with POI than in controls (odds ratio [OR], 1.830; 95% CI, 1.040-3.221; P = 0.040; and OR, 1.797; 95% CI, 1.055-3.060; P = 0.031, respectively). The AT1R 1166AC genotype occurred more frequently in participants with POI than in controls (OR, 3.171; 95% CI, 1.562-6.436; P = 0.002). Comparing the combined genotype frequencies of ACE/AT1R revealed that the frequencies of ID/AA, ID/AC, and II/AC were higher in participants than in controls (OR, 1.916; 95% CI, 1.053-3.485; P = 0.043; OR, 3.544; 95% CI, 1.207-10.407; P = 0.036; and OR, 7.875; 95% CI, 2.224-27.881; P = 0.001, respectively). The TT/AC genotype for combined genotyping of AGT/AT1R was more frequently observed in the POI group than in the control group (OR, 3.472; 95% CI, 1.450-8.313; P = 0.006). In multifactor dimensionality reduction–based haplotype analysis, the I-T-C genotype of ACE/AGT/AT1R was a possible predisposing factor for POI (OR, 4.678; 95% CI, 1.721-12.717; P = 0.002).

Conclusions: This study demonstrates that polymorphisms in the renin-angiotensin system are related to the prevalence of POI. Thus, these renin-angiotensin system genes may serve as a novel marker for predicting the development of POI.

© 2013 by The North American Menopause Society.

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