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Menopause:
doi: 10.1097/gme.0b013e318275025e
Original Articles

Effect of soy isoflavone supplementation on menopausal quality of life

Amato, Paula MD1; Young, Ronald L. MD1; Steinberg, Francene M. PhD2; Murray, Michael J. MD3; Lewis, Richard D. PhD4; Cramer, Margaret A. MD4; Barnes, Stephen PhD5; Ellis, Kenneth J. PhD6; Shypailo, Roman J. BS6; Fraley, Joe Kennard MPH6; Konzelmann, Karen L. MS6; Fischer, Joan G. PhD4; LaSalle, Colette RD2; Smith, Elliot O’Brian PhD6; Wong, William W. PhD6

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Abstract

Objective: The purpose of this study was to assess the effect of soy isoflavone supplementation on quality of life in postmenopausal women.

Methods: A multicenter, randomized, double-blind, placebo-controlled 24-month trial was conducted to assess the effect of 80 or 120 mg of daily aglycone hypocotyl soy isoflavone supplementation on quality of life in 403 postmenopausal women using a validated Menopause-Specific Quality of Life questionnaire.

Results: Menopause-Specific Quality of Life domain scores at 1 year and 2 years were similar to baseline. There were no differences in domain scores among treatment groups.

Conclusions: Soy isoflavone supplementation offers no benefit to quality of life in postmenopausal women.

© 2013 by The North American Menopause Society.

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