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Effect of soy isoflavone supplementation on menopausal quality of life

Amato, Paula MD1; Young, Ronald L. MD1; Steinberg, Francene M. PhD2; Murray, Michael J. MD3; Lewis, Richard D. PhD4; Cramer, Margaret A. MD4; Barnes, Stephen PhD5; Ellis, Kenneth J. PhD6; Shypailo, Roman J. BS6; Fraley, Joe Kennard MPH6; Konzelmann, Karen L. MS6; Fischer, Joan G. PhD4; LaSalle, Colette RD2; Smith, Elliot O’Brian PhD6; Wong, William W. PhD6

doi: 10.1097/gme.0b013e318275025e
Original Articles

Objective: The purpose of this study was to assess the effect of soy isoflavone supplementation on quality of life in postmenopausal women.

Methods: A multicenter, randomized, double-blind, placebo-controlled 24-month trial was conducted to assess the effect of 80 or 120 mg of daily aglycone hypocotyl soy isoflavone supplementation on quality of life in 403 postmenopausal women using a validated Menopause-Specific Quality of Life questionnaire.

Results: Menopause-Specific Quality of Life domain scores at 1 year and 2 years were similar to baseline. There were no differences in domain scores among treatment groups.

Conclusions: Soy isoflavone supplementation offers no benefit to quality of life in postmenopausal women.

From the 1Oregon Health and Science University, Portland, OR; 2University of California, Davis, CA; 3Kaiser Foundation Research Institute, Sacramento, CA; 4University of Georgia, Athens, GA; 5University of Alabama, Birmingham, AL; and 6US Department of Agriculture/Agricultural Research Service, Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX.

Received May 30, 2012; revised and accepted September 6, 2012.

Funding/support: This study was supported by the US Department of Agriculture/Cooperative State Research, Education, and the Extension Service/Initiatives for Future Agriculture and Food Systems (grant 2001-52102-11255) and by the National Institutes of Health General Clinical Research Center (grant M01-RR00188).

Financial disclosure/conflicts of interest: W.W.W. is a consultant to Nestle. All other authors report no conflicts of interest.

Address correspondence to: Paula Amato, MD, Oregon Health and Science University, 3303 SW Bond Avenue, CH10F, Portland, OR 97239-4501. E-mail:

© 2013 by The North American Menopause Society.