Objective: The purpose of this study was to assess the effect of soy isoflavone supplementation on quality of life in postmenopausal women.
Methods: A multicenter, randomized, double-blind, placebo-controlled 24-month trial was conducted to assess the effect of 80 or 120 mg of daily aglycone hypocotyl soy isoflavone supplementation on quality of life in 403 postmenopausal women using a validated Menopause-Specific Quality of Life questionnaire.
Results: Menopause-Specific Quality of Life domain scores at 1 year and 2 years were similar to baseline. There were no differences in domain scores among treatment groups.
Conclusions: Soy isoflavone supplementation offers no benefit to quality of life in postmenopausal women.
From the 1Oregon Health and Science University, Portland, OR; 2University of California, Davis, CA; 3Kaiser Foundation Research Institute, Sacramento, CA; 4University of Georgia, Athens, GA; 5University of Alabama, Birmingham, AL; and 6US Department of Agriculture/Agricultural Research Service, Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX.
Received May 30, 2012; revised and accepted September 6, 2012.
Funding/support: This study was supported by the US Department of Agriculture/Cooperative State Research, Education, and the Extension Service/Initiatives for Future Agriculture and Food Systems (grant 2001-52102-11255) and by the National Institutes of Health General Clinical Research Center (grant M01-RR00188).
Financial disclosure/conflicts of interest: W.W.W. is a consultant to Nestle. All other authors report no conflicts of interest.
Address correspondence to: Paula Amato, MD, Oregon Health and Science University, 3303 SW Bond Avenue, CH10F, Portland, OR 97239-4501. E-mail: firstname.lastname@example.org