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Low-dose rosuvastatin improves the functional and morphological markers of atherosclerosis in asymptomatic postmenopausal women with dyslipidemia

Igase, Michiya MD, PhD1,2; Kohara, Katsuhiko MD, PhD1,2,3; Tabara, Yasuharu PhD2,3,4; Nagai, Tokihisa MD, PhD1; Ochi, Namiko MD, PhD1,2; Kido, Tomoko MD1,2; Ochi, Masayuki MD, PhD1; Miki, Tetsuro MD, PhD1,2,3

doi: 10.1097/gme.0b013e318259c04e
Original Articles
Editorial

Objective: Several large-scale studies have shed light on the primary preventive efficacy of statins against atherosclerotic diseases in the course of treatment of dyslipidemia. However, this efficacy in the management of dyslipidemia in relatively low-risk patients, particularly in women, has not been clarified. Here, we investigated the efficacy of dyslipidemia treatment with a statin on three indices that are widely used to assess atherosclerosis in postmenopausal women: carotid intima-media thickness (CIMT), arterial stiffness index β of the common carotid artery (carotid stiffness β), and brachial artery pulse wave velocity (baPWV).

Methods: The study enrolled 51 postmenopausal women aged 55 years or older with dyslipidemia. The participants were randomly divided into two treatment groups and received a single daily administration of 2.5 mg of rosuvastatin or no statin therapy as control.

Results: At baseline, the groups did not significantly differ with regard to the three indices. At the third and 12th months of treatment, both carotid stiffness β and baPWV values were significantly lower than those of the control group. As for CIMT, the value was significantly lower in the statin group than in the control group at 12 months of treatment. These changes were in conjunction with a significant decrease in low-density lipoprotein cholesterol. Interestingly, changes in CIMT during the 12-month period were significantly correlated with changes in high-sensitivity C-reactive protein during the 3-month period independently of lipid profile.

Conclusions: The potent statin improves baPWV and carotid stiffness β, in addition to CIMT (surrogate markers of coronary artery disease), in postmenopausal women with low-risk dyslipidemia. Further studies to clarify the common mechanisms underlying the link between cholesterol-lowering therapy and atherosclerosis in postmenopausal women are required.

From the 1Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan; 2Antiaging Center, Ehime University Hospital, Toon, Ehime, Japan; 3Proteo-Medicine Research Center, Ehime University, Toon, Ehime, Japan; and 4Department of Fundamental Medical Science, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.

Received December 9, 2011; revised and accepted April 4, 2012.

Funding/support: This study was supported by a grant-in-aid for scientific research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

Financial disclosure/conflicts of interest: None reported.

Address correspondence to: Michiya Igase, MD, PhD, Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan. E-mail: migase@m.ehime-u.ac.jp

©2012The North American Menopause Society