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Menopause:
doi: 10.1097/gme.0b013e31825d65c5
Original Articles

Frequency of FRAX risk factors in osteopenic postmenopausal women with and without history of fragility fracture

Baró, Francesc MD1; Cano, Antonio MD2; Sánchez Borrego, Rafael MD3; Ferrer, Javier MD4; González Rodríguez, Silvia Pilar MD5; Neyro, Jose Luis MD6; Rodriguez Bueno, Esteban MD7; Sancho, Cristina8; Inaraja, Verónica8; Fernández, Cristina MD9; Corral, Carlos MD8; for the FROSPE Study Group

Editorial
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Abstract

Objective: Fractures associated with bone fragility represent a major public health concern. Although the risk of bone fracture is higher among patients with osteoporosis, the number of fractures is usually higher among patients with osteopenia due to its higher prevalence.

Methods: This is an observational case series study that compares the frequencies of nonskeletal risk factors for osteoporotic fractures in osteopenic postmenopausal women with previous clinical fragility fractures (FFs) and osteopenic postmenopausal women without previous FF. Risk factors included in the FRAX algorithm and other selected risk factors, including asymptomatic vertebral fractures, were evaluated.

Results: A total of 735 (50.3% with prior FF and 49.7% without prior FF) postmenopausal women were evaluated (median age, 60 y; mean bone mineral density [BMD] femoral neck T score of −1.67). The frequency of the following risk factors was significantly higher among women with FF—FRAX algorithm: age, use of corticosteroids, and BMD femoral neck T score; other factors: Hispanic ethnicity, falls during the last year, and BMD lumbar T score. In addition, the frequency of previously undetected asymptomatic vertebral fractures was four times higher among women with a history of FF.

Conclusions: The results of the present study support the need to assess the presence of asymptomatic vertebral fractures and BMD T scores in osteopenic postmenopausal women. The risk evaluation of this subpopulation can be accomplished by using some of the risk factors included in the FRAX algorithm combined with other conventional risk factors.

©2012The North American Menopause Society

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