Skip Navigation LinksHome > September 2012 - Volume 19 - Issue 9 > Association of ALOX12 and ALOX15 gene polymorphisms with age...
Menopause:
doi: 10.1097/gme.0b013e31824e6160
Original Articles

Association of ALOX12 and ALOX15 gene polymorphisms with age at menarche and natural menopause in Chinese women

Xiao, Wenjin MS1,2; Ke, Yaohua PhD1; He, Jinwei MS1; Zhang, Hao PhD1; Yu, Jinbo MS1; Hu, Weiwei MS1; Gu, Jiemei MS1; Yue, Hua PhD1; Wang, Chun PhD1; Hu, Yunqiu MS1; Li, Miao MS1; Fu, Wenzhen MS1; Liu, Yujuan BS1; Zhang, Zhenlin PhD1

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Abstract

Objective: Lipoxygenase (LOX) is one of the major metabolic enzymes for arachidonic acid, which has been reported to be associated with many postmenopausal and many hormone-related diseases. In rats, selective inhibition of the LOX pathway led to defective ovulation. However, little is known about the association of the LOX-related genes with menstruation in women. In this study, we investigated the possible association of two key gene (ALOX12 and ALOX15) polymorphisms with age of menarche and menopause in Chinese women.

Methods: Six tagging single nucleotide polymorphisms (SNPs) of ALOX12 and five SNPs of ALOX15 were genotyped. The association of single SNPs and haplotypes in two candidate genes and age at menarche (AAM) variation was tested in 401 Chinese nuclear families using the quantitative transmissing disequilibrium test. Furthermore, the association between these SNPs and haplotypes and age at natural menopause (AANM) in 710 postmenopausal Chinese women was measured.

Results: Using family- and population-based statistical procedures, significant association was found between SNPs rs312462 in ALOX12 and AAM in nuclear families (P = 0.043), and three SNPs (rs2292350, rs312470, and rs312462) in ALOX12 were significantly associated with AANM in postmenopausal women (P = 0.012, P = 0.045, and P = 0.033, respectively). Haplotype analyses corroborated our single SNP results (P = 0.030). However, we failed to find a significant association between ALOX15 gene polymorphisms and AAM as well as AANM (P > 0.05).

Conclusions: Our present results suggest that genetic variations in ALOX12 are associated with both the onset and cessation of menstruation in Chinese women living in Shanghai.

©2012The North American Menopause Society

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