Skip Navigation LinksHome > September 2012 - Volume 19 - Issue 9 > Association between kinase insert domain-containing receptor...
Menopause:
doi: 10.1097/gme.0b013e318248f2e8
Original Articles

Association between kinase insert domain-containing receptor polymorphisms (−604T>C, 1192G>A, 1719A>T) and premature ovarian failure in Korean women

Rah, HyungChul DVM, PhD1,2; Jeon, Young Joo MS1,2; Choi, Youngsok PhD1,3; Shim, Sung Han PhD1,3; Ko, Jung Jae PhD1; Yoon, Tae Ki MD, PhD3; Cha, Sun Hee MD, PhD4; Kim, Nam Keun PhD1,2

Collapse Box

Abstract

Objective: The aim of the study was to investigate whether the −604T>C, 1192G>A, and 1719A>T polymorphisms in the kinase insert domain-containing receptor (KDR) gene confer risk for premature ovarian failure (POF) in Korean women.

Methods: DNA samples from 133 POF patients and 230 controls were genotyped for the three KDR single nucleotide polymorphisms by polymerase chain reaction–restriction fragment length polymorphism analysis.

Results: The POF patients had significantly increased frequencies of the KDR −604TC and −604TC + CC genotypes (odds ratio [OR], 1.975; 95% CI, 1.219-3.201 and OR, 1.948; 95% CI, 1.221-3.109, respectively) and of the −604TC + CC/1192GG combined genotype (OR, 2.271; 95% CI, 1.359-3.795) and a decreased frequency of the 1192GA genotype (OR, 0.457; 95% CI, 0.231-0.905) compared with the controls. The genotype frequency of the 1719A>T polymorphism was not significantly different between the two groups. The frequencies of the KDR −604C/1192G/1719T, −604C/1192G, and −604C/1719T haplotypes (OR, 3.319; 95% CI, 1.564-7.041; OR, 2.083; 95% CI, 1.351-3.212; and OR, 1.979; 95% CI, 1.073-3.649, respectively) were significantly higher among POF patients than controls, whereas the −604T/1719T haplotype frequency (OR, 0.657; 95% CI, 0.472-0.915) was lower among POF patients.

Conclusions: Carriers of the KDR −604C variant allele (−604TC and −604TC + CC genotypes; −604TC + CC/1192GG combined genotype; −604C/1192G/1719T haplotype, −604C/1192G haplotype, −604C/1719T haplotype) are consistently more prevalent among POF patients than among controls, suggesting that the KDR −604C allele may increase the risk of POF development in Korean women.

©2012The North American Menopause Society

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.