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Cardiometabolic benefits of exercise training in an experimental model of metabolic syndrome and menopause

Sanches, Iris Callado MSc1; de Oliveira Brito, Janaina MSc1; Candido, Geórgia Orsi MSc2; da Silva Dias, Danielle BSc1; Jorge, Luciana MSc2; Irigoyen, Maria-Cláudia MD, PhD2; De Angelis, Kátia PhD1

doi: 10.1097/gme.0b013e3182358c9c
Original Articles

Objective: The aim of this study was to investigate the cardiometabolic effects of exercise training in ovariectomized hypertensive rats both submitted and not submitted to fructose overload.

Methods: Spontaneously hypertensive ovariectomized rats were divided into sedentary and trained (THO) groups submitted to normal chow and sedentary and trained groups submitted to fructose overload (100 g/L in drinking water for 19 wk). Exercise training was performed on a treadmill (8 wk). Arterial pressure (AP) was directly recorded. Cardiovascular autonomic control was evaluated through pharmacological blockade (atropine and propranolol) and in the time and frequency domains by spectral analysis.

Results: The THO group presented reduced AP (approximately 16 mm Hg) and enhanced cardiac vagal tonus (approximately 49%) and baroreflex sensitivity (approximately 43%) compared with the sedentary hypertensive ovariectomized group. Exercise training attenuated metabolic impairment, resting tachycardia, cardiac and vascular sympathetic increases, and baroreflex sensitivity decrease induced by fructose overload in hypertensive rats. However, the trained hypertensive ovariectomized group submitted to fructose overload presented higher AP (approximately 32 mm Hg), associated with baroreflex sensitivity (approximately 69%) and parasympathetic dysfunctions compared with the THO group.

Conclusions: These data suggest that the metabolic disorders in hypertensive rats after ovarian hormone deprivation could blunt and/or attenuate some exercise training benefits.

These findings suggest that metabolic disorders in hypertensive rats after ovarian hormone deprivation could blunt and/or attenuate some exercise training benefits.

From the 1Laboratory of Translational Physiology, Nove de Julho University, Sao Paulo, Brazil; and 2Hypertension Unit, Heart Institute, University of Sao Paulo, Sao Paulo, Brazil.

Received July 14, 2011; revised and accepted August 31, 2011.

Funding/support: This study was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES-PROSUP) and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP: 2007/57595-5, 2007/52419-4, 2010/17188-4). K. De Angelis and M.C. Irigoyen are the recipients of CNPq-BPQ fellowships.

Financial disclosure/conflicts of interest: None reported.

Address correspondence to: Kátia De Angelis, PhD, Nove de Julho University–Science Rehabilitation Program, Av. Francisco Matarazzo, 612, 1° andar, CEP 05001-100, Sao Paulo, SP, Brazil. E-mail: prof.kangelis@uninove.br

©2012The North American Menopause Society