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Adolescent pregnancy is associated with osteoporosis in postmenopausal women

Cho, Geum Joon MD; Shin, Jung-Ho MD, PhD; Yi, Kyong Wook MD; Park, Hyun Tae MD; Kim, Tak MD; Hur, Jun Young MD; Kim, Sun Haeng MD

doi: 10.1097/gme.0b013e3182337150
Original Articles

Objective: Adolescence is a critical time of life to accumulate bone for peak bone mass. Factors that may interfere with bone mass accrual during this period may increase the risk of osteoporosis. Several studies have reported that pregnancy during adolescence has detrimental effects on bone mass measurements after pregnancy. However, less is known about how adolescent pregnancy affects bone mineral density (BMD) and osteoporosis after menopause. The aim of this study was to evaluate the association between adolescent pregnancy and osteoporosis in postmenopausal Korean women.

Methods: We conducted a cross-sectional study of 719 postmenopausal women, all of whom were enrolled in the Korean National Health and Nutrition Examination Survey in 2008. BMD was measured using dual-energy x-ray absorptiometry.

Results: Postmenopausal women with histories of adolescent pregnancy had lower BMD of the total hip, femoral neck, and lumbar spine than did women without histories of adolescent pregnancy. Multivariate logistic regression analyses revealed that postmenopausal women with history of adolescent pregnancy were at increased risk of osteoporosis (odds ratio, 2.20; 95% CI, 1.12-4.30) compared with women without history of adolescent pregnancy after adjustments for age, body mass index, marital status, education level, household income, alcohol intake, smoking history, exercise, age at menarche, age at menopause, parity, hormone therapy use, intake of energy and calcium, and vitamin D level.

Conclusions: Adolescent pregnancy may be a predictor of osteoporosis in postmenopausal women.

Adolescent pregnancy is associated with an increased risk of osteoporosis in postmenopausal women.

From the Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.

Received June 19, 2011; revised and accepted August 18, 2011.

Financial disclosure/conflicts of interest: None reported.

Address correspondence to: Jung-Ho Shin, MD, PhD, Department of Obstetrics and Gynecology, Korea University Guro Hospital, Korea University College of Medicine, 80, Guro-dong, Guro-gu, Seoul 152-703, Korea. E-mail: shinjh@korea.ac.kr

©2012The North American Menopause Society