Research is ongoing into the mechanisms of abnormal uterine bleeding, including bleeding from organic etiologies, where there is an intrinsic uterine lesion. Most of the current studies are focused on abnormalities of angiogenesis. By elucidating these mechanisms, targeted therapies can be developed. This article reviews the literature on pathologic mechanisms involved in bleeding from organic etiologies.
From the UMDNJ-New Jersey Medical School, Newark, NJ.
Received August 19, 2010; revised and accepted September 23, 2010.
Financial disclosure/conflicts of interest: None reported.
Presented at the Premeeting Symposium: "Abnormal Uterine Bleeding: Causality, Diagnosis & Management"; October 6, 2010.
Address correspondence to: Debra S. Heller, MD, Department of Pathology, UH/E158, UMDNJ-New Jersey Medical School, 185 South Orange Ave., Newark, NJ 07103. E-mail firstname.lastname@example.org