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Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a perspective, randomized, placebo-controlled study

Giordano, Domenico MD1; Corrado, Francesco MD2; Santamaria, Angelo MD2; Quattrone, Simona MD1; Pintaudi, Basilio MD3; Di Benedetto, Antonino MD3; D'Anna, Rosario MD2

doi: 10.1097/gme.0b013e3181e8e1b1
Brief Reports

Objective: The aim of this study was to evaluate whether myo-inositol, an insulin-sensitizing substance, may improve some features of metabolic syndrome in postmenopausal women.

Methods: Eighty postmenopausal women affected by the metabolic syndrome were enrolled prospectively in the study and treated with diet plus supplementation of myo-inositol (2 g BID plus diet: intervention group) or with diet plus placebo (control group) for 6 months. They were evaluated at baseline and after 6 months for insulin resistance (homeostasis model assessment ratio [HOMA] insulin resistance), lipid profile, and blood pressure.

Results: Myo-inositol plus diet improved systolic and diastolic blood pressure, HOMA index, cholesterol, and triglyceride serum levels with highly significant differences, compared with the groups treated only with diet and placebo. In the group treated with myo-inositol, a decrease in diastolic blood pressure (−11%), HOMA index (−75%), and serum triglycerides (−20%) and an improvement in high-density lipoprotein cholesterol (22%) were shown.

Conclusions: Supplementation with myo-inositol may be considered a reliable option in the treatment of metabolic syndrome in postmenopausal women.

Supplementation with myo-inositol may be considered a reliable option in the treatment of metabolic syndrome in postmenopausal women.

From the 1Policlinico Hospital, Reggio di Calabria, Italy; and Departments of 2Obstetrics and Gynecological Sciences and 3Internal Medicine, University of Messina, Messina, Italy.

Received March 16, 2010; revised and accepted April 19, 2010.

Funding/support: This work was supported by the University of Messina (Italy).

Financial disclosure/conflicts of interest: None reported.

Address correspondence to: Rosario D'Anna, MD, viale Italia, n. 2, 98124 Messina, Italy. E-mail: rosariodanna@tin.it

©2011The North American Menopause Society