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Menopause:
doi: 10.1097/gme.0b013e3181b5540e
Brief Report

"Persistence" improves the 60-day amenorrhea marker of entry to late-stage menopausal transition for women aged 40 to 44 years

Taffe, John R. PhD1; Cain, Kevin C. PhD2; Mitchell, Ellen S. PhD, RN2; Woods, Nancy F. PhD, RN, FAAN2; Crawford, Sybil L. PhD3; Harlow, Siobán D. PhD4

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Abstract

Objective: The ReSTAGE collaboration evaluated four menstrual markers of entry to late-stage menopausal transition. The aim of this study was to assess the additional usefulness of "persistence" in relation to a clinically accessible menstrual marker of late menopausal transition, taking age into account.

Methods: In this study, a secondary analysis of menstrual calendar data in two ReSTAGE-collaborating studies with comparatively low age at beginning of menstrual calendar observation was performed.

Results: Sixty days of amenorrhea is as useful for predicting time to the final menstrual period as the currently accepted 90-day marker for women older than 45 years. For those aged between 40 and 44 years, recurrence of the 60-day marker within the next 10 cycles is a better indicator than a single occurrence of the 60-day marker or the 90-day marker.

Conclusions: Sixty-day amenorrhea is as reliable a marker of late menopausal transition as the traditional 90-day marker for women older than 45 years. For those aged 40 to 44 years, keeping menstrual records to check for a recurrence of the 60-day marker will be useful.

©2010The North American Menopause Society

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