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doi: 10.1097/01.gme.0000248704.30204.33

Raloxifene improves the ovariectomy-induced impairment in endothelium-dependent vasodilation

Takahashi, Kazuhiro MD, PhD1; Mori-Abe, Akiko MD, PhD1; Takata, Keiko MD1; Ohta, Tsuyoshi MD1; Kawagoe, Jun MD, PhD1; Tsutsumi, Seiji MD, PhD1; Ohmichi, Masahide MD, PhD2; Kurachi, Hirohisa MD, PhD1

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Objective: To examine the effect of raloxifene on the endothelial dysfunction caused by surgical menopause.

Design: Ten premenopausal women who underwent gynecological surgery with ovariectomy were divided into two groups. Five participants used raloxifene (60 mg/d) for 7 days staring 1 week after the surgery, and the other five participants did not use raloxifene. We examined the changes in flow-mediated dilatation (FMD) of the brachial artery using ultrasonography. Vasodilation in response to nitroglycerin was also studied. We also measured the brachial-ankle pulse wave velocity to examine the change in arterial stiffness in these participants before and after surgical menopause.

Results: In both the raloxifene and control groups, a significant decrease in FMD was observed 1 week after the surgery. Although no further changes in FMD were observed in the control group at 2 weeks after surgery, FMD was significantly increased in the raloxifene group. No remarkable changes in nitroglycerin or brachial-ankle pulse wave velocity were observed after surgery in either group.

Conclusions: Raloxifene rapidly restored FMD that was impaired after surgical menopause. Therefore, raloxifene may be effective for ameliorating and maintaining endothelial function in premenopausal women who undergo ovariectomy.

©2007The North American Menopause Society


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