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Predicting participation in prospective studies of ovarian aging

Nelson, Deborah B. PhD1 4; Sammel, Mary D. ScD1; Freeman, Ellen W. PhD2; Liu, Li MD, MS3; Langan, Elizabeth BA3; Gracia, Clarisa R. MD4

Menopause:
Articles
Abstract

Objective: Identifying clinical markers and characteristics of the transition to menopause is an important woman’s health issue, and recent long-term, prospective, cohort studies are just beginning to offer insight into methods of predicting the transition to menopause. One of the major challenges of conducting prospective cohort studies is the problem of attrition—both the retention of study participants and the influence of dropouts on the final study results. We conducted this systematic analysis to: 1) identify baseline predictors of subsequent long-term participation, and 2) determine the demographic, psychosocial, and hormonal differences between participants and dropouts among a group of premenopausal women enrolled in a longitudinal study of ovarian aging.

Design: Using data from the Penn Ovarian Aging study, premenopausal women aged 35 to 47 enrolled in the study were classified as either Active (full participants), Skipped, or Dropped participants based on their visit pattern during a 4-year study interval.

Results: Most of the demographic and psychosocial variables did not significantly differ between the Active, Skipped, or Dropped groups. There was no racial difference in study participation. The Dropouts were more likely to have a high school education and were less likely to report menopause symptoms compared with the Actives (P < 0.01). The Skipped group reported more anxiety (P < 0.05), and members were more likely to have less than a high school education compared with the Actives (P < 0.03). Hormone levels (estradiol, follicle-stimulating hormone, luteinizing hormone, dehydroepiandrosterone, testosterone) at enrollment were within the premenopausal range and did not significantly differ among the three study groups. These findings remained after adjustment for covariates and hormone levels in multivariate analyses.

Conclusions: Education, anxiety levels and menopause symptoms at baseline differed marginally between the women participating fully and those who dropped out or skipped multiple assessments. These findings are important and indicate that long-term study participation rates do not differ substantially by racial group or any of the other demographic or hormonal characteristics examined.

In Brief

In this prospective study of ovarian aging, educational level, anxiety, and reported menopause symptoms at baseline differed marginally between the women participating fully and those who dropped out or skipped multiple assessments. These findings are important and indicate that long-term study participation does not differ substantially by racial group or any other demographic or hormonal characteristics.

Author Information

From the 1 Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, 2 Department of Obstetrics & Gynecology and Department of Psychiatry, 3 Center for Research in Reproduction and Women’s Health, and 4 Obstetrics & Gynecology, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, PA.

Received September 2, 2003; revised and accepted February 18, 2004.

This study was supported by General Clinical Research Center grants R01-AG-12745 and 2 M01 RR-00040-37.

Address correspondence to: Deborah B. Nelson, PhD, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Medical Center, 423 Guardian Drive, 921 Blockley Hall, Philadelphia, PA 19104-6021. E-mail: dnelson@cceb.med.upenn.edu.

©2004The North American Menopause Society