Skip Navigation LinksHome > October 2014 - Volume 24 - Issue 5 > Activity of trametinib in K601E and L597Q BRAF mutation-posi...
Melanoma Research:
doi: 10.1097/CMR.0000000000000099
Short Communications

Activity of trametinib in K601E and L597Q BRAF mutation-positive metastatic melanoma

Bowyer, Samantha E.a,*; Rao, Aparna D.c,*; Lyle, Megane; Sandhu, Shahneenc; Long, Georgina V.e,f; McArthur, Grant A.c,d; Raleigh, Jeanette M.c; Hicks, Rodney J.c,d; Millward, Michaela,b

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Abstract

BRAF and MEK inhibitors are not established treatments for non-V600 mutation-positive metastatic melanoma. We carried out a retrospective analysis of efficacy and safety in four patients with BRAF K601E and one patient with L597Q mutation-positive metastatic melanoma treated with the MEK inhibitor trametinib. Three patients achieved a RECIST partial response, including the patient with an L597Q mutation. Paired biopsies available in one of the five patients showed reduced phospho-ERK signalling and this corresponded to a metabolic response on 18F-fluorodeoxyglucose-PET scanning. Trametinib toxicity was manageable. Trametinib has antitumour activity in patients with BRAF K601E and L597Q mutation-positive metastatic melanoma.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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