Medical Care

Skip Navigation LinksHome > March 2014 - Volume 52 - Issue 3 > Weight Loss and Outcomes in Wait-listed, Medically Managed,...
Medical Care:
doi: 10.1097/MLR.0000000000000070
Original Articles

Weight Loss and Outcomes in Wait-listed, Medically Managed, and Surgically Treated Patients Enrolled in a Population-based Bariatric Program: Prospective Cohort Study

Padwal, Raj S. MD, MSc*,†; Rueda-Clausen, Christian F. MD, PhD*,†; Sharma, Arya M. MD, PhD*,†; Agborsangaya, Calypse B. MSc*,†; Klarenbach, Scott MD, MSc*; Birch, Dan W. MD; Karmali, Shahzeer MD; McCargar, Linda§; Majumdar, Sumit R. MD, MPH*,†

Supplemental Author Material
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Background: Multidisciplinary bariatric care is increasingly being delivered in Canada within publicly funded regional programs. Demand is high, wait lists are long, and clinical effectiveness is unknown.

Objective: To examine the “real-world” outcomes associated with a publicly funded, population-based regional bariatric (medical and surgical) program.

Research Design: Prospective observational cohort.

Subjects: Five hundred consecutive patients (150 wait-listed, 200 medically treated, 150 surgically treated) from the Edmonton Weight Wise program were enrolled.

Measures: The primary outcome was weight change (kg). Between-group changes were analyzed using multivariable regression adjusted for age, sex, and baseline weight and “last-observation-carried-forward” was used for missing data. Subjects transitioning between groups (wait-list to medical or medical to surgery) were censored when crossing over.

Results: At baseline, mean age was 43.7±9.6 years, mean body mass index was 47.9±8.1 kg/m2, and 88% were female. A total of 412 subjects (82%) completed 2-year follow-up and 143 (29%) subjects crossed over to the next treatment phase. Absolute and relative (% of baseline) mean weight reductions were 1.5±8.5 kg (0.9±6.1%) for wait-listed, 4.1±11.6 kg (2.8±8.1%) for medically treated, and 22.0±19.7 kg (16.3±13.5%) for surgically treated (P<0.001) subjects. For surgery, weight reductions were 7.0±9.7 kg (5.8±7.9%) with banding, 21.4±16.0 kg (16.4±11.6%) with sleeve gastrectomy, and 36.6±19.5 kg (26.1±12.2%) with gastric bypass (P<0.001). Rates of hypertension, diabetes, and dyslipidemia decreased to a significantly greater degree with surgery than medical management (P<0.001) and stayed the same or increased in wait-listed subjects.

Conclusions: Population-based bariatric care, particularly bariatric surgery, was clinically effective. Weight and cardiometabolic risk was relatively stable wait-listed patients receiving “usual care.”

© 2014 by Lippincott Williams & Wilkins.


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