Skip Navigation LinksHome > March 2011 - Volume 49 - Issue 3 > Complications Among Colorectal Cancer Survivors: SF-6D Prefe...
Medical Care:
doi: 10.1097/MLR.0b013e31820194c8
Brief Report

Complications Among Colorectal Cancer Survivors: SF-6D Preference-Weighted Quality of Life Scores

Hornbrook, Mark C. PhD*; Wendel, Christopher S. MA†; Coons, Stephen Joel PhD‡§; Grant, Marcia PhD, RN¶; Herrinton, Lisa J. PhD∥; Mohler, M. Jane PhD†**††; Baldwin, Carol M. PhD, PN‡‡; McMullen, Carmit K. PhD*; Green, Sylvan B. MD**§§; Altschuler, Andrea PhD∥; Rawl, Susan M. PhD, RN¶¶; Krouse, Robert S. MD†††§§

Collapse Box


Background: Societal preference-weighted health-related quality of life (HRQOL) scores enable comparing multidimensional health states across diseases and treatments for research and policy.

Objective: To assess the effects of living with a permanent intestinal stoma, compared with a major bowel resection, among colorectal cancer (CRC) survivors.

Research Design: Cross-sectional multivariate linear regression analysis to explain preference-weighted HRQOL scores.

Subjects: In all, 640 CRC survivors (≥5 years) from 3 group model health maintenance organizations; ostomates and nonostomates with colorectal resections for CRC were matched on gender, age (±5 years), time since diagnosis, and tumor site (rectum vs. colon).

Measures: SF-6D scoring system was applied to Medical Outcomes Study Short Form-36 version 2 (SF-36v2); City of Hope Quality of Life-Ostomy; and Charlson-Deyo comorbidity index.

Methods: Survey of CRC survivors linked to respondents’ clinical data extracted from health maintenance organization files.

Results: Response rate was 52%. Ostomates and nonostomates had similar sociodemographic characteristics. Mean SF-6D score was 0.69 for ostomates, compared with 0.73 for nonostomates (P < 0.001), but other factors explained this difference. Complications of initial cancer surgery, and previous year comorbidity burden, and hospital use were negatively associated with SF-6D scores, whereas household income was positively associated.

Conclusions: CRC survivors’ SF-6D scores were not associated with living with a permanent ostomy after other factors were taken into account. Surgical complications, comorbidities, and metastatic disease lowered the preference-weighted HRQOL of CRC survivors with and without ostomies. Further research to understand and reduce late complications from CRC surgeries as well as associated depression is warranted.

© 2011 Lippincott Williams & Wilkins, Inc.


Article Tools


Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.