The Agency for Healthcare Research and Quality, in expanding its efforts to advance methods for comparative effectiveness research (CER), convened a second invitational symposium in June 2009 through its Developing Evidence to Inform Decisions About Effectiveness (DEcIDE) network. A distinguished Planning Committee set the agenda, reviewed more than 70 abstracts, and invited almost 30 speakers; the program emphasized issues of clinical heterogeneity and longitudinal outcomes, including patient-reported measures.
Conference papers covered a varied set of points about 3 major areas of CER: study design and data collection issues; statistical and analytic techniques; and applications to policy and clinical decision-making. Both primary data collection and analyses of databases (including electronic health records and distributed networks) are crucial for the CER agenda. Methods advances enable investigators to pay greater attention to important population subgroups, including persons of low literacy, non-English speaking patients, or the frail elderly. Both established and newer statistical techniques—eg, propensity scoring and various types of modeling, including Bayesian approaches—offer analysts improved ways to address issues such as confounding and measurement bias. Finally, some articles provided guidance for and examples of extending CER into newer realms, such as evaluations of medical devices or surgical procedures, and providing better information for decision-makers, clinicians, and patients.
From the RTI International, Research Triangle Park, NC.
This research was funded through a contract from the Agency for Healthcare Research and Quality to the RTI International DEcIDE Center (Contract No. AHRQ Contract No. HHSA 290 2005 0036 I PS-13).
The author of this paper is responsible for its content. Statements in the paper should not be construed as endorsement by the Agency for Healthcare Research and Quality or the US Department of Health and Human Services of a particular drug, device, test, treatment, or other clinical service.
Reprints: Kathleen N. Lohr, PhD, RTI International, 3040 Cornwallis Road, PO Box 21294, Research Triangle Park, NC 27709–2194. E-mail: email@example.com.