Medical Care

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Medical Care:
doi: 10.1097/MLR.0b013e3181653d43
Original Article

The Effectiveness of Guideline Implementation Strategies on Improving Antipsychotic Medication Management for Schizophrenia

Owen, Richard R. MD*†; Hudson, Teresa PharmD*†; Thrush, Carol EdD‡; Thapa, Purushottam MD, MPH†§; Armitage, Tracey MS*; Landes, Reid D. PhD¶

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Objectives: To compare the effectiveness of a conceptually-based, multicomponent “enhanced” strategy with a “basic” strategy for implementing antipsychotic management recommendations of VA schizophrenia guidelines.

Methods: Two VA medical centers in each of 3 Veterans Integrated Service Networks were randomized to either a basic educational implementation strategy or the enhanced strategy, in which a trained nurse promoted provider guideline adherence and patient compliance. Patients with acute exacerbation of schizophrenia were enrolled and assessed at baseline and 6 months and their medical records were abstracted; 291 participants were included in analyses. Logistic regression models were developed for rates of: (1) switching patients from first-generation antipsychotics (FGA) to second-generation antipsychotics (SGA), and (2) guideline-concordant antipsychotic dose.

Results: Of participants prescribed FGAs at baseline, those at enhanced sites were significantly more likely than participants at basic sites to have an SGA added to the FGA during the study (29% vs. 8%; adjusted OR = 7.7; 95% CI: 2.0–30.1), but were not significantly more likely to be switched to monotherapy with an SGA (29% vs. 23%). Guideline-concordant antipsychotic dosing was not significantly affected by the intervention.

Conclusions: The enhanced guideline implementation strategy increased addition of SGAs to FGA therapy, but did not significantly increase guideline-recommended switching from FGA to SGA monotherapy. Antipsychotic dosing was not significantly altered. The study illustrates the challenges of changing clinical behavior. Strategies to improve medication management for schizophrenia are needed, and must incorporate recommendations likely to emerge from recent research suggesting comparable effectiveness of SGAs and FGAs.

© 2008 Lippincott Williams & Wilkins, Inc.


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