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A principal component analysis of coagulation after trauma

Kutcher, Matthew E. MD; Ferguson, Adam R. PhD; Cohen, Mitchell J. MD

Journal of Trauma and Acute Care Surgery: May 2013 - Volume 74 - Issue 5 - p 1223–1230
doi: 10.1097/TA.0b013e31828b7fa1
AAST 2012 Plenary Papers
Editor's Choice

BACKGROUND: Clotting factor abnormalities underlying acute traumatic coagulopathy are poorly understood, with application of traditional regression techniques confounded by colinearity. We hypothesized that principal components analysis (PCA), a pattern-finding and data reduction technique, would identify clinically predictive patterns in the complex clotting factor milieu after trauma.

METHODS: Plasma was prospectively collected from 163 critically injured trauma patients. Prothrombin; factors V, VII, VIII, IX, X; D-dimer; activated and native protein C; and antithrombin III levels were assayed and subjected to nonlinear PCA to identify principal components (PCs).

RESULTS: Of 163 patients, 19.0% were coagulopathic on admission. PCA identified 3 significant PCs, accounting for 67.5% of overall variance. PC1 identified global clotting factor depletion; PC2 the activation of protein C and fibrinolysis; and PC3 factor VII elevation and VIII depletion. PC1 score correlated with penetrating injury and injury severity, predicting coagulopathy (odds ratio [OR], 4.67; p < 0.001) and mortality (OR, 1.47; p = 0.032). PC2 score correlated with injury severity, acidosis, and shock, and significantly predicted ventilator-associated pneumonia (OR, 1.59; p = 0.008), acute lung injury (OR, 2.24; p < 0.001), multiorgan failure (OR, 1.83; p = 0.002), and mortality (OR, 1.62; p = 0.006) but was not associated with international normalized ratio (INR)–based or partial thromboplastin time (PTT)–based coagulopathy (p > 0.200). PC3 did not significantly predict outcomes.

CONCLUSION: PCA identifies distinct patterns of coagulopathy: depletion coagulopathy predicts mortality and INR/PTT elevation, while fibrinolytic coagulopathy predicts infection, end-organ failure, and mortality, without detectable differences in INR or PTT. While depletion coagulopathy is intuitive, fibrinolytic coagulopathy may be a distinct but often overlapping entity with differential effects on outcomes.

LEVEL OF EVIDENCE: Prognostic study, level III.

From the Department of Surgery (M.E.K., M.J.C.), San Francisco General Hospital; and Brain and Spinal Injury Center (BASIC) (A.R.F.), Department of Neurological Surgery, University of California, San Francisco, California.

Submitted: October 8, 2012, Revised: January 29, 2013, Accepted: January 30, 2013.

This study was presented at the annual meeting of the American Association for the Surgery of Trauma, September 12–15, 2012, in Kauai, Hawaii.

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Address for reprints: Mitchell Jay Cohen, MD, Department of Surgery, Ward 3A San Francisco General Hospital 1001 Potrero Ave, Room 3C-38 San Francisco, CA 94110; email:

© 2013 Lippincott Williams & Wilkins, Inc.