Skip Navigation LinksHome > April 2013 - Volume 74 - Issue 4 > Acute kidney injury is associated with early cytokine change...
Journal of Trauma and Acute Care Surgery:
doi: 10.1097/TA.0b013e31828586ec
Original Articles

Acute kidney injury is associated with early cytokine changes after trauma

Bihorac, Azra MS, MD; Baslanti, Tezcan Ozrazgat PhD; Cuenca, Alex G. MD, PhD; Hobson, Charles E. MD, MHA; Ang, Darwin MD, PhD; Efron, Philip A. MD; Maier, Ronald V. MD; Moore, Frederick A. MD; Moldawer, Lyle L. PhD

Supplemental Author Material
Collapse Box


BACKGROUND: Acute kidney injury (AKI) occurs in 26% of trauma patients and is associated with increased mortality and risk for nosocomial infections (NCIs). We compared serial plasma cytokine levels in patients with posttraumatic AKI to determine whether the early cytokine changes are associated with the occurrence of AKI and NCI.

METHODS: We performed a secondary analysis of the Inflammation and the Host Response to Injury database to include adult blunt trauma patients who had available plasma proteomic analyses. AKI was defined by the RIFLE (Risk, Injury, Failure, Loss, and End-stage Kidney) classification, which requires a 50% increase in serum creatinine. The association among AKI, NCI, and plasma cytokines was analyzed using a mixed model analyses and logistic regression.

RESULTS: Among 147 patients in the cohort, prevalence of NCI was 73% and 52% for patients with and without AKI, respectively. In mixed model analyses adjusted for clinical factors, AKI patients developed significant early increase in IL-1ra, IL-8, MCP1, and IL-6; early decrease in sTNFR2; and late decrease in IL-1ra, IL-4, and IL-6 concentrations, compared with patients without AKI and regardless of NCI. The change in cytokine pattern differed for sIL1R2, CXCL1, and MIP1β, depending on the occurrence of NCI. Patients with AKI and NCI had lower early and late sIL1R2 and higher early and late CXCL1 and MIP1β levels. Within the first 24 hours of injury, adding plasma levels of IL-1ra, IL-8, MCP1, IL-6, and sTNFR2 to clinical parameters of injury severity provided a predictive model for AKI superior to clinical model only (p < 0.001).

CONCLUSION: AKI trauma patients exhibit simultaneous changes in proinflammatory and anti-inflammatory serial plasma cytokine levels. The predictive model for AKI that combines plasma cytokine levels with clinical data within 24 hours of injury requires further prospective validation in larger studies.

LEVEL OF EVIDENCE: Prognostic study, level III.

© 2013 Lippincott Williams & Wilkins, Inc.

Follow Us


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.