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Epidemiology of moderate-to-severe penetrating versus closed traumatic brain injury in the Iraq and Afghanistan wars

Orman, Jean A. ScD; Geyer, Dennis MD; Jones, John; Schneider, Eric B. PhD; Grafman, Jordan PhD; Pugh, Mary Jo PhD; DuBose, Joseph MD

Journal of Trauma and Acute Care Surgery: December 2012 - Volume 73 - Issue 6 - p S496–S502
doi: 10.1097/TA.0b013e318275473c
Original Articles

BACKGROUND: US combat operations in Iraq and Afghanistan have resulted in a greater proportion of service members with head and neck wounds caused by explosions compared with that of previous wars. Although penetrating traumatic brain injury (TBI) is frequently associated with these wounds, the epidemiology of penetrating TBI from these conflicts has not been well described.

METHODS: The Joint Theater Trauma Registry was queried for January 2003 through December 2010 to identify all patients with moderate-to-severe brain injury with a maximum Abbreviated Injury Scale (AIS) score of the head of 3 or greater and a diagnosis of penetrating or closed TBI in accordance with the Department of Defense Traumatic Brain Injury Surveillance definition. The epidemiology of these injuries was examined, including demographics, TBI severity, overall injury severity, and surgical interventions provided.

RESULTS: A total of 1,255 TBI patients (774 penetrating, 481 closed) meeting criteria were identified. Penetrating brain injuries were more severe, more likely to be battle related, and less likely to be isolated injuries than a group of moderate-to-severe closed TBIs within the same range of anatomic injury severity. During the 5-year period of the Iraq war with the largest numbers of TBIs (2004–2008), the numbers of penetrating TBIs exceeded closed TBIs by a ratio of 2:1. During the 3-year period of the Afghanistan war with the greatest numbers of TBIs (2008–2010), the ratio of penetrating to closed TBIs was substantially lower, approximately 1.3:1.

CONCLUSION: This study represents the first comprehensive report on the epidemiology of moderate-to-severe penetrating and closed TBIs resulting from the wars in Iraq and Afghanistan using Joint Theater Trauma Registry data. With the maturing theater of conflicts, penetrating TBIs were substantially less predominant compared with closed TBIs. While this finding may reflect changes in the use of protective measures and tactics or improvements in diagnosis of closed TBIs, additional research is needed to identify the reason for this shift and the subsequent effect on outcome after combat-related TBIs.

LEVEL OF EVIDENCE: Epidemiologic study, level III.

From the US Army Institute of Surgical Research (J.A.O., J.J.), Fort Sam Houston; Department of Epidemiology and Biostatistics (J.A.O., M.J.P.), University of Texas Health Science Center; Neurosurgery Service (D.G.), Department of Surgery, San Antonio Military Medical Center; South Texas Veterans Health Care System (M.J.P.), San Antonio, Texas; Center for Surgical Trials and Outcomes Research (E.B.S.), Johns Hopkins School of Medicine; R. Adams Cowley Shock Trauma Center (J.D.), University of Maryland Medical System, Baltimore, Maryland; Rehabilitation Institute of Chicago (J.G.); Department of Physical Medicine and Rehabilitation (J.G.), Northwestern University, Chicago, Illinois.

The opinions or assertions contained herein are the private views of the author and are not to be construed as official or as reflecting the views of the Department of the Army, the Department of Defense, or the Department of Veterans Affairs.

Address for reprints: Jean A. Orman, ScD, MPH, US Army Institute of Surgical Research, 3698 Chambers Pass, ATTN: MCMR-SRR, Fort Sam Houston, TX 78234-6315; email: Jean.A.Orman@amedd.army.mil.

© 2012 Lippincott Williams & Wilkins, Inc.