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Skip Navigation LinksHome > April 1996 - Volume 40 - Issue 4 > The Effects of Positive End-Expiratory Pressure on Intrapulm...
Journal of Trauma-Injury Infection & Critical Care:
Article

The Effects of Positive End-Expiratory Pressure on Intrapulmonary Shunt and Ventilatory Deadspace in Nonhypoxic Trauma Patients

Vigil, Anthony R. MD; Clevenger, Frederick W. MD, FACS

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Abstract

Controversy exists regarding the routine use of positive end-expiratory pressure (PEEP) in mechanically ventilated patients. We hypothesized that nonhypoxic patients receiving 5-cm H2 O PEEP would have improved shunt and PaO2 /FIO2 ratios (P/F), without an increased dead space to tidal volume ratio (VD/VT) versus patients receiving no PEEP. Forty-four trauma patients were randomized to receive 5-cm H2 O PEEP (PEEP) or 0-cm H2 O PEEP (ZEEP). Shunt VD/VT and P/F were measured at 0, 12, 24, 36, and 48 hours after intubation and after extubation. PEEP and ZEEP comparisons used Student's t test and the General Linear Models procedure. Shunt was significantly increased at t = 0 and at extubation in the PEEP group. At extubation, the PEEP group demonstrated significantly higher VD/VT and poorer P/F ratios. After correction for baseline values, no statistically significant differences were noted in spite of a trend toward worsening pulmonary function in all measured parameters. These results suggest that routine use of 5-cm H2 O PEEP in mechanically ventilated trauma patients is not necessary.

© Williams & Wilkins 1996. All Rights Reserved.

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