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Aberrations in Post-trauma Monocyte (Mo) Subpopulation: Role in Septic Shock Syndrome.

MILLER-GRAZIANO, CAROL L. Ph.D.; SZABO, CYONGYI M.D.; KODYS, KAREN B.A.; GRIFFEY, KATHERINE M.D.
Journal of Trauma-Injury Infection & Critical Care: December 1990
SESSION III: IMMUNOLOGICAL CONSEQUENCES: PDF Only

Appearance of increased proportions of monocytes bearing the 72kd(FcRI) receptor for IgG correlated to aberrant monocyte (Mo) functions, depressed immune functions, and poor clinical outcome. The trauma patients' FeRI+ Mo subpopulation produced the majority of their elevated IL-6, TNF[alpha], TGF[beta] and PGE2, IgG stimulation of patients' Mo through FeRI not only stimulated TNF[alpha], IL-6, and PGE2 levels, but also greatly augmented the levls of these monokines produced after subsequent bacterial challenge. Post-trauma increased IL-6 levels can lead to polyclonal E-cell activation and high levels of circulating, nonspecific IgG as seen in trauma patients. This nonspecific IgG triggers the FeRI on the increased numbers of FeRI+ Mo leading to ever-increasing monokine levels. IL-4 was found to downregulate patients' FeRI+ Mo production of mediators. The cycle of altered cytokine levels, increased FeRI+ Mo numbers, elevated IgG, and augmented triggering of FeRI+ Mo may be broken by addition of IL-4.

(C) Williams & Wilkins 1990. All Rights Reserved.