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Journal of Thoracic Oncology:
doi: 10.1097/JTO.0b013e31824fea2c
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Tubular Tumor Growth Along Entire Biopsy Track of Brain Metastasis

Wesseling, Frederik W.R. BS*; de Kunder, Suzanne L. BS; Schijns, Olaf E.M.G. MD; Baumert, Brigitta G. MD, PhD*‡; Postma, Alida A. MD, PhD§

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*Department of Radiation Oncology, Maastricht University Medical Centre, Maastricht, The Netherlands

Department of Neurosurgery (MAASTRO), Maastricht University Medical Centre, Maastricht, The Netherlands

GROW, School for Oncology and Developmental Biology, and Maastricht University Medical Centre, Maastricht, The Netherlands

§Department of Radiology, Maastricht University Medical Centre, Maastricht, The Netherlands.

Disclosure: The authors declare no conflicts of interest.

Address for correspondence: Alida A. Postma, MD, PhD, MUMC Department of Radiology, PO Box 5800, 6202 AZ Maastricht, The Netherlands. E-mail:

A 58-year-old woman presented with severe fatigue, head-ache, diplopia, and a transient paresis of the left leg.

Magnetic resonance imaging revealed a solitary right-sided lesion of the cerebral peduncle, without further signs of systemic disease or primary tumor. A stereotactic biopsy of the lesion was performed. Histopathological examination showed adenocarcinoma, presumably of lung origin. The metastasis was treated with stereotactic radiotherapy.

Follow-up magnetic resonance imaging (after 3 months) showed a decrease in tumor size but a new lesion along the biopsy track.

Tumor seeding after biopsy is more commonly described in non-central nervous system oncology, but is rarely seen in intracerebral metastatic disease.1,2

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1. Karlsson B, Ericson K, Kihlström L, Grane P. Tumor seeding following stereotactic biopsy of brain metastases. Report of two cases. J Neurosurg. 1997;87:327–330

2. Marx T, Rainov NG, Heidecke V, Burkert W. Secondary tumor formation after stereotactic biopsy for intracerebral metastatic disease. Surg Neurol. 2001;55:41–45

Brain metastasis; Biopsy; Tumor seeding; Adenocarcinoma

© 2012International Association for the Study of Lung Cancer


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