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Journal of Thoracic Oncology:
doi: 10.1097/JTO.0b013e3182259207
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Computed Tomography Perfusion: A New Method to Evaluate Response to Therapy in Lung Cancer

Fraioli, Francesco MD*; Vetere, Simone MD*; Anile, Marco MD*†; Venuta, Federico MD†

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Departments of *Radiological Sciences and †Thoracic Surgery, University of Rome, “Sapienza,” Rome, Italy.

Disclosure: The authors declare no conflicts of interest.

Address for correspondence: Francesco Fraioli, MD, Department of Radiological Sciences, University of Rome, “Sapienza”, V. Le R. Elena 324, Rome, Italy. E-mail:

A 60-year-old man with lung adenocarcinoma, judged inoperable, underwent perfusion computed tomography (pCT) scan before and after 3 and 6 months of conventional and antiangiogenic chemotherapy (Paclitaxel 175 mg/mq and Bevacizumab 7.5 mg/kg). The treatment started immediately after the first pCT examination and was repeated every 21 days for 6 months (Figures 1 and 2).

Figure 1
Figure 1
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Figure 2
Figure 2
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pCT parameters adopted by applying dedicated perfusional software were blood flow, blood volume, time to peak, and permeability.1

Objective response in clinical practice is evaluated by RECIST, measuring only the maximal axial diameter of the lesions.

Changes, as demonstrated in this case, suggest that pCT should be considered as part of the response evaluation with antiangiogenesis agents.

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1. Ng QS, Goh V, Fichte H, et al. Lung cancer perfusion at multi-detector row CT: reproducibility of whole tumor quantitative measurements. Radiology 2006;239:547–553.

Cited By:

This article has been cited 1 time(s).

Expert Review of Anticancer Therapy
Advances and perspectives in lung cancer imaging using multidetector row computed tomography
Coche, E
Expert Review of Anticancer Therapy, 12(): 1313-1326.
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© 2011International Association for the Study of Lung Cancer


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