Skip Navigation LinksHome > September 2011 - Volume 6 - Issue 9 > Computed Tomography Perfusion: A New Method to Evaluate Resp...
Journal of Thoracic Oncology:
doi: 10.1097/JTO.0b013e3182259207
Image of the Month

Computed Tomography Perfusion: A New Method to Evaluate Response to Therapy in Lung Cancer

Fraioli, Francesco MD*; Vetere, Simone MD*; Anile, Marco MD*†; Venuta, Federico MD†

Free Access
Article Outline
Collapse Box

Author Information

Departments of *Radiological Sciences and †Thoracic Surgery, University of Rome, “Sapienza,” Rome, Italy.

Disclosure: The authors declare no conflicts of interest.

Address for correspondence: Francesco Fraioli, MD, Department of Radiological Sciences, University of Rome, “Sapienza”, V. Le R. Elena 324, Rome, Italy. E-mail: fraioli.francesco@gmail.com

A 60-year-old man with lung adenocarcinoma, judged inoperable, underwent perfusion computed tomography (pCT) scan before and after 3 and 6 months of conventional and antiangiogenic chemotherapy (Paclitaxel 175 mg/mq and Bevacizumab 7.5 mg/kg). The treatment started immediately after the first pCT examination and was repeated every 21 days for 6 months (Figures 1 and 2).

Figure 1
Figure 1
Image Tools
Figure 2
Figure 2
Image Tools

pCT parameters adopted by applying dedicated perfusional software were blood flow, blood volume, time to peak, and permeability.1

Objective response in clinical practice is evaluated by RECIST, measuring only the maximal axial diameter of the lesions.

Changes, as demonstrated in this case, suggest that pCT should be considered as part of the response evaluation with antiangiogenesis agents.

Back to Top | Article Outline

REFERENCE

1. Ng QS, Goh V, Fichte H, et al. Lung cancer perfusion at multi-detector row CT: reproducibility of whole tumor quantitative measurements. Radiology 2006;239:547–553.

Cited By:

This article has been cited 1 time(s).

Expert Review of Anticancer Therapy
Advances and perspectives in lung cancer imaging using multidetector row computed tomography
Coche, E
Expert Review of Anticancer Therapy, 12(): 1313-1326.
10.1586/ERA.12.112
CrossRef
Back to Top | Article Outline

© 2011International Association for the Study of Lung Cancer

Login

Article Tools

Images

Share

Other Ways to Connect

Twitter
twitter.com/JTOonline

 



Visit JTO.org on your smartphone. Scan this code (QR reader app required) with your phone and be taken directly to the site.

 For additional oncology content, visit LWW Oncology Journals on Facebook.