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Ruco, Luigi MD; Scarpino, Stefania PhD; Natoli, Guido MD
University “La Sapienza”; 00139 Rome; Italy; firstname.lastname@example.org
Disclosure: The authors declare no conflict of interest.
Last year in the New England Journal of Medicine Chen et al.1 stated that a five-gene quantitative polymerase-chain-reaction assay stratified patients with early-stage lung cancer into low-risk and high-risk groups. Indeed, they concluded that patient with surgically resected non-small cell lung cancer that were classified as first group might be spared from adjuvant treatment. In contrast, Michiels and Hill2 observed that to correctly validate such signature a different and independent group of patients needed to be used. In addition, Dobbin3 noted that the reuse of survival data to identify a predictor genes provide substantial bias. Taken together, these observations provide a rationale for an independent validation of such molecular signature. To do that, we analyzed a population of 38 non-small cell lung cancer patients with stage I disease and untreated after lobar resection. Using methods as described,1 we did not find difference among 19 patients who had cancer-related death within 30months after resection and 19 patients who were alive within 40 months after resection (5-gene high risk = 7/12 versus 8/11; Fisher’s exact test p = 1).
Luigi Ruco, MD
Stefania Scarpino, PhD
Guido Natoli, MD
University “La Sapienza”
© 2009International Association for the Study of Lung Cancer
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