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Journal of Thoracic Oncology:
doi: 10.1097/JTO.0b013e31816e23e6
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Epithelioid Sarcoma Metastatic to the Lung As Pulmonary Cysts Without Other Metastatic Manifestation

Choi, Si Young MD*; Kim, Yong Hwan MD*; Kwon, Jong Bum MD†; Suh, Jong Hui MD*; Shin, Ok-Ran MD‡; Hong, Sook Hee MD§

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Department of Thoracic and Cardiovascular Surgery, *Uijeongbu St. Mary’s Hospital, †Daejeon St. Mary’s Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea; ‡Department of Clinical Pathology, Uijeongbu St. Mary’s Hospital, §Division of Medical Oncology, Department of Internal Medicine, Uijeongbu St. Mary’s Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea.

Disclosure: This paper was supported through grants from the Catholic University of Korea, College of Medicine.

Address for correspondence: Yong Hwan Kim, MD, Uijeongbu St. Mary’s Hospital 65-1, Geumo-dong, Uijeongbu, Gyeonggi-do, 480-821, South Korea. E-mail: cmccs@naver.com

A 35-year-old man presented with deep ulceration on the scalp for 3 months. Physical examinations and routine laboratory investigations were unremarkable, except for the noduloulcerative lesion in the right parieto-occipital area (Figure 1).

Figure 1
Figure 1
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Microscopically, a skin biopsy revealed this tumor was suggestive of epithelioid sarcoma. Immunohistochemically, the tumor cells stained for cytokeratin, epithelial membrane antigen, vimentin, and CD34 (Figure 2). The specimen stained negative with CD68. Therefore, this lesion was diagnosed as an epithelioid sarcoma.

Figure 2
Figure 2
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Chest radiography revealed no remarkable findings. Chest computed tomography (CT) revealed bilateral multiple thin-walled cysts measuring up to 1.5 cm in diameter (Figures 3A, B). No nodules, pleural lesions, or enlarged lymph nodes were found. Brain CT and positron emission tomography-CT were performed, and no distant metastasis or enlarged lymph nodes were found. The patient underwent video-assisted thoracoscopic surgery to diagnose whether pulmonary cystic mass represented metastatic lesions (Figure 3C). Microscopically, lung biopsy specimen had a same feature of the skin lesion. All tumor cells presented only within the pulmonary interstitium (Figure 4). Immunohistochemically, the tumor cells stained for cytokeratin, epithelial membrane antigen, vimentin, and CD34. The specimen stained negative with CD68 and thyroid transcription factor-1.

Figure 3
Figure 3
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Figure 4
Figure 4
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Pulmonary cystic metastasis from epitheloid sarcoma without other metastatic manifestation was extremely rare condition. Two cases of cystic pulmonary metastases of epithelioid sarcomas have been described.1,2 Three possible mechanisms for the development of malignant cysts have been proposed: (i) excavation of a nodular tumor through discharge of the necrotic material inside; (ii) infiltration of malignant cells into the walls of a preexisting benign pulmonary bulla; or (iii) distension of alveoli and small airways by partial bronchial obstruction through the ball-valve effect of the tumor.1,2 The presence of tumor cells within pulmonary interstitium suggests that the pathogenesis of the metastatic cysts in the present case may have involved the third mechanism and it would be early manifestation of hematogenous metastasis of epithelioid sarcomas.

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REFERENCES

1. Kikuchi E, Kinoshita I, Yamazaki K, et al. Epithelioid sarcoma presenting as pulmonary cysts with cancer antigen 125 expression. Respirology 2006;11:826–829.

2. Hasegawa S, Inui K, Kamakari K, Kotoura Y, Suzuki K, Fukumoto M. Pulmonary cysts as the sole metastatic manifestation of soft tissue sarcoma: case report and consideration of the pathogenesis. Chest 1999;116:263–265.

Keywords:

Epithelioid sarcoma; Pulmonary cyst; Pulmonary metastasis; Cystic metastasis

© 2008International Association for the Study of Lung Cancer

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