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Journal of Thoracic Oncology:
doi: 10.1097/JTO.0000000000000179
Original Articles

Joint Effects of Environmental Exposures and Familial Susceptibility to Lung Cancer in Chinese Never Smoking Men and Women

Tse, Lap Ah*; Yu, Ignatius Tak-sun*; Rothman, Nathaniel; Ji, Bu-Tian; Qiu, Hong*; Wang, Xiao-rong*; Hu, Wei; Au, Joseph Siu-kie; Lan, Qing

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Objectives: Previous epidemiological studies had limited power to investigate the joint effects of individual environmental risk factors and familial susceptibility to lung cancer. This study aimed to address this shortcoming.

Methods: We recruited 345 never smoking lung cancer cases and 828 community referents. We developed a collective environmental exposure index by assigning a value of 1 to subjects at high risks regarding environmental risk factors and 0 otherwise, and then summed over using weights equivalent to the excess odds ratio. Potential additive and multiplicative interactions between environmental exposure index and family cancer history were examined.

Results: Compared with “low environmental exposure and without family cancer history”, the odds ratio was 6.80 (95% confidence interval = 3.31–13.98) for males who had high environmental exposures but without family cancer history, whereas it increased to 30.61 (95% confidence interval = 9.38–99.87) if they also had a positive family history. The corresponding associations became weaker in never smoking females. No multiplicative interaction was observed for both genders and an additive interaction was restricted among males.

Conclusions: This study developed a novel environmental exposure index that offers sufficient interest deserving further studies on the interactions between environmental exposures and familial susceptibility to lung cancer risk.

Copyright © 2014 by the European Lung Cancer Conference and the International Association for the Study of Lung Cancer.


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