Skip Navigation LinksHome > May 2014 - Volume 9 - Issue 5 > ALK/EML4 Fusion Gene May Be Found in Pure Squamous Carcinoma...
Journal of Thoracic Oncology:
doi: 10.1097/JTO.0000000000000109
Brief Reports

ALK/EML4 Fusion Gene May Be Found in Pure Squamous Carcinoma of the Lung

Caliò, Anna MD*; Nottegar, Alessia MD*; Gilioli, Eliana MD*; Bria, Emilio MD; Pilotto, Sara MD; Peretti, Umberto MD; Kinspergher, Stefania MD; Simionato, Francesca MD; Pedron, Serena BaSc*; Knuutila, Sakari MD; Tortora, Giampaolo MD; Eccher, Albino MD*; Santo, Antonio MD; Tondulli, Luca MD; Inghirami, Giorgio MD§; Tabbò, Fabrizio MD§; Martignoni, Guido MD*; Chilosi, Marco MD*; Scarpa, Aldo MD, PhD*‖; Brunelli, Matteo MD, PhD*

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Introduction: The report of cases of lung squamous cell cancers harboring anaplastic lymphoma kinase (ALK) gene rearrangements raises the question whether this histologic subtype should be also evaluated for such molecular predictive test.

Methods: A consecutive series of 40 lung pure squamous cell carcinomas were analyzed for ALK gene status by fluorescence in situ hybridization. Squamous differentiation was validated using an immunohistochemical panel including n-p63 (p40), cytokeratin (CK) 5/6, sex-determining region Y (SRY)-Box2 (SOX2), thyroid transcription factor 1, CK7, and Napsin-A.

Results: Squamous differentiation was confirmed in all tumors as they stained positive for n-p63 and CK5/6 and negative for thyroid transcription factor 1 and Napsin-A. One of 40 cases (2.5%) showed an ALK rearrangement on fluorescence in situ hybridization analysis.

Conclusions: ALK translocation may be found in lung pure squamous cell carcinomas. Our data suggest the opportunity to test ALK rearrangements on biopsy samples harboring squamous cell cancer differentiation.

Copyright © 2014 by the European Lung Cancer Conference and the International Association for the Study of Lung Cancer.


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