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Journal of Thoracic Oncology:
doi: 10.1097/JTO.0000000000000031
Original Articles

Maximum Standardized Uptake Value on FDG-PET Is a Strong Predictor of Overall and Disease-Free Survival for Non–Small-Cell Lung Cancer Patients after Stereotactic Body Radiotherapy

Takeda, Atsuya MD, PhD*; Sanuki, Naoko MD*; Fujii, Hirofumi MD, PhD; Yokosuka, Noriko MD; Nishimura, Shuichi MD*; Aoki, Yousuke RTT*; Oku, Yohei PhD*; Ozawa, Yukihiko MD, PhD; Kunieda, Etsuo MD, PhD§

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Abstract

Introduction:

The maximum standardized uptake value (SUVmax) on 18F-fluorodeoxyglucose positron emission tomography is a predictor for overall survival (OS) in non–small-cell lung cancer (NSCLC) after resection. We investigated the association between SUVmax and outcomes in NSCLC after stereotactic body radiotherapy.

Methods:

Between 2005 and 2012, 283 patients with early NSCLC (T1a-2N0M0) were treated with stereotactic body radiotherapy; the total doses were 40 to 60 Gy in five fractions. Patients who underwent staging 18F-fluorodeoxyglucose positron emission tomography scans by a single scanner and were followed up for more than or who died within 6 months were eligible. The optimal threshold SUVmax was calculated for each outcome. Outcomes were analyzed using the Kaplan–Meier method and log-rank test. Prognostic significance was assessed by univariate and multivariate analyses.

Results:

One hundred fifty-two patients were eligible. Median follow-up was 25.3 (range, 1.3–77.4) months. Local, regional, and distant recurrences, cancer-specific deaths, and deaths from other reasons occurred in 14, 11, 27, 21, and 31 patients, respectively. The optimal threshold SUVmax for local, regional, and distant recurrences, and disease-free survival (DFS), cancer-specific survival, and OS were 2.47 to 3.64. Outcomes of patients with SUVmax lower than each threshold were significantly better than those with higher SUVmax (all p<0.005): 3-year DFS rates were 93.0% versus 58.3% (p<0.001) and 3-year OS rates were 86.5% versus 42.2% (p<0.001), respectively. By multivariate analysis, higher SUVmax was a significantly worse predictor for DFS (p<0.01) and OS (p=0.04).

Conclusions:

SUVmax was a predictor for DFS and OS. A high SUVmax may be considered for intensive treatment to improve outcomes.

Copyright © 2013 by the International Association for the Study of Lung Cancer

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