Skip Navigation LinksHome > December 2013 - Volume 8 - Issue 12 > The Central Nervous System as a Sanctuary Site in ALK-Positi...
Journal of Thoracic Oncology:
doi: 10.1097/JTO.0000000000000029
Brief Reports

The Central Nervous System as a Sanctuary Site in ALK-Positive Non–Small-Cell Lung Cancer

Gainor, Justin F. MD*; Ou, Sai-Hong Ignatius MD, PhD; Logan, Jennifer NP, MS*; Borges, Lawrence F. MD; Shaw, Alice T. MD, PhD*

Collapse Box


Anaplastic lymphoma kinase (ALK) gene rearrangements define a distinct molecular subset of non–small-cell lung cancer that is highly responsive to treatment with the ALK inhibitor crizotinib. Recently, it has been recognized that the brain is a frequent site of relapse among ALK-positive patients treated with crizotinib. In this report, we expand on these observations and present a series of ALK-positive patients with two distinct forms of metastatic, central nervous system involvement: intramedullary spinal cord metastasis and leptomeningeal carcinomatosis.

Copyright © 2013 by the European Lung Cancer Conference and the International Association for the Study of Lung Cancer.


Article Tools


Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Other Ways to Connect



Visit on your smartphone. Scan this code (QR reader app required) with your phone and be taken directly to the site.

 For additional oncology content, visit LWW Oncology Journals on Facebook.