Skip Navigation LinksHome > November 2013 - Volume 8 - Issue 11 > Stereotactic Body Radiation Therapy for Primary Lung Cancers...
Journal of Thoracic Oncology:
doi: 10.1097/JTO.0b013e3182a47181
Original Articles

Stereotactic Body Radiation Therapy for Primary Lung Cancers >3 Centimeters

Cuaron, John J. MD*; Yorke, Ellen D. PhD*; Foster, Amanda BA*; Hsu, Meier MS*; Zhang, Zhigang PhD*; Liu, Fan PhD*; Jackson, Andrew PhD*; Mychalczak, Borys MD*; Rosenzweig, Kenneth E. MD; Wu, Abraham J. MD*; Rimner, Andreas MD*

Collapse Box

Abstract

Introduction:

A retrospective analysis of the outcomes of stereotactic body radiation therapy (SBRT) in the treatment of large (>3 cm) non–small-cell lung cancers (NSCLCs).

Methods:

Between February 2007 and November 2011, 63 patients with T2-T4N0 NSCLC were treated with SBRT. Toxicity was graded per Common Terminology Criteria for Adverse Events, version 4.0. Local failure-free survival (LFFS), recurrence-free survival, and overall survival curves were estimated using the Kaplan–Meier method and univariate analysis was performed using Cox regression.

Results:

Median follow-up was 16.9 months. One- and 2-year LFFS was 88.8% and 75.7%, 1- and 2-year recurrence-free survival was 59.0% and 41.6%, and 1- and 2-year overall survival was 77.1% and 57.6%, respectively. Planning target volume less than 106 cm3 was associated with a significantly higher 1- and 2-year LFFS (p =0.05). Grade 2 or higher acute and late pulmonary toxicities occurred in 19.3% and 19.3% of patients, respectively, and were not associated with common dose–volume parameters; 22.8% of patients developed grade 2 or higher chest wall pain, which was significantly associated with chest wall V30 70 cm3 or more (p = 0.03).

Conclusions:

SBRT for larger NSCLC tumors achieves high LFFS with acceptable toxicity. LFFS was worse with planning target volume 106 cm3 or more. Grade 2 or higher chest wall pain was associated with chest wall V30 70 cm3 or more.

Copyright © 2013 by the International Association for the Study of Lung Cancer

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Other Ways to Connect

Twitter
twitter.com/JTOonline

 



Visit JTO.org on your smartphone. Scan this code (QR reader app required) with your phone and be taken directly to the site.

 For additional oncology content, visit LWW Oncology Journals on Facebook.