Skip Navigation LinksHome > November 2013 - Volume 8 - Issue 11 > Radioprotection of Lung Tissue by Soy Isoflavones
Journal of Thoracic Oncology:
doi: 10.1097/JTO.0b013e3182a4713e
Original Articles

Radioprotection of Lung Tissue by Soy Isoflavones

Hillman, Gilda G. PhD*; Singh-Gupta, Vinita PhD*; Lonardo, Fulvio MD; Hoogstra, David J. BA*; Abernathy, Lisa M. BS*†; Yunker, Christopher K. BA*; Rothstein, Shoshana E. BA*; Rakowski, Joseph PhD*; Sarkar, Fazlul H. PhD; Gadgeel, Shirish MD§; Konski, Andre A. MD*; Joiner, Michael C. PhD*

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Abstract

Introduction:

Radiation-induced pneumonitis and fibrosis have restricted radiotherapy for lung cancer. In a preclinical lung tumor model, soy isoflavones showed the potential to enhance radiation damage in tumor nodules and simultaneously protect normal lung from radiation injury. We have further dissected the role of soy isoflavones in the radioprotection of lung tissue.

Methods:

Naive Balb/c mice were treated with oral soy isoflavones for 3 days before and up to 4 months after radiation. Radiation was administered to the left lung at 12 Gy. Mice were monitored for toxicity and breathing rates at 2, 3, and 4 months after radiation. Lung tissues were processed for histology for in situ evaluation of response.

Results:

Radiation caused damage to normal hair follicles, leading to hair loss in the irradiated left thoracic area. Supplementation with soy isoflavones protected mice against radiation-induced skin injury and hair loss. Lung irradiation also caused an increase in mouse breathing rate that was more pronounced by 4 months after radiation, probably because of the late effects of radiation-induced injury to normal lung tissue. However, this effect was mitigated by soy isoflavones. Histological examination of irradiated lungs revealed a chronic inflammatory infiltration involving alveoli and bronchioles and a progressive increase in fibrosis. These adverse effects of radiation were alleviated by soy isoflavones.

Conclusion:

Soy isoflavones given pre- and postradiation protected the lungs against adverse effects of radiation including skin injury, hair loss, increased breathing rates, inflammation, pneumonitis and fibrosis, providing evidence for a radioprotective effect of soy.

Copyright © 2013 by the International Association for the Study of Lung Cancer

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