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Serum prolidase activity and oxidativeantioxidative status in LeggCalvePerthes disease

Altay, Mehmet Akifa; Erturk, Cemila; Aksoy, Nurtenb; Taskin, Abdullahb; Bilge, Alia; Celik, Hakimb; Isikan, Ugur Erdema

Journal of Pediatric Orthopaedics B:
doi: 10.1097/BPB.0b013e32834493df

We aimed to find out that whether collagen turnover is altered in the context of Legg–Calve–Perthes disease (LCPD) by evaluating serum prolidase activity. We also investigated the correlation between collagen turnover and oxidative–antioxidative status in LCPD. Plasma prolidase activity, total oxidant status (TOS), total antioxidant capacity, and oxidative stress index (OSI) were determined for 39 patients with LCPD and 40 healthy controls. Serum prolidase activity, TOS, and OSI were higher, but TAC was lower in patients with LCPD compared with controls. Prolidase activity was positively correlated with TOS and OSI levels. Serum prolidase activity is significantly associated with LCPD.

Author Information

aDepartments of Orthopaedic Surgery

bBiochemistry, Sanliurfa, Harran University Faculty of Medicine, Turkey

Correspondence to Mehmet Akif Altay, MD, Emniyet Caddesi Koc Apt., No: 40/10, Yenisehir, 63100 Sanliurfa, Turkey Tel: +90 414 314 11 70; fax: +90 414 315 11 81; e-mail:;

© 2011 Lippincott Williams & Wilkins, Inc.