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Chemotherapy for Generalized Infantile Myofibromatosis With Visceral Involvement

Wu, Susan Y. MSIII*; McCavit, Timothy L. MD†,‡; Cederberg, Kevin MD§; Galindo, Rene L. MD, PhD†,∥,¶; Leavey, Patrick J. MD†,‡

Journal of Pediatric Hematology/Oncology: July 2015 - Volume 37 - Issue 5 - p 402–405
doi: 10.1097/MPH.0000000000000132
Clinical and Laboratory Observations

Infantile myofibromatosis (IM) is most commonly limited to cutaneous lesions that resolve spontaneously. However, generalized IM with visceral involvement, which has a reported mortality rate as high as 73%, has been successfully treated with a combination of methotrexate and vinblastine. Here we report the further efficacy of low-dose methotrexate and vinblastine in 2 pediatric patients with IM and visceral involvement and review the literature describing chemotherapy for these patients.

*University of Texas Southwestern Medical School

Department of Pediatrics, Division of Hematology-Oncology

Departments of §Radiology


Molecular Biology, University of Texas Southwestern Medical Center at Dallas

The Center for Cancer and Blood Disorders and Children’s Medical Center Dallas, Dallas, TX

The authors declare no conflict of interest.

Reprints: Patrick J. Leavey, MD, Department of Pediatrics, Division of Hematology-Oncology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9063 (e-mail:

Received July 17, 2013

Accepted January 24, 2014

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