Skip Navigation LinksHome > July 2015 - Volume 37 - Issue 5 > Chemotherapy for Generalized Infantile Myofibromatosis With...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0000000000000132
Clinical and Laboratory Observations

Chemotherapy for Generalized Infantile Myofibromatosis With Visceral Involvement

Wu, Susan Y. MSIII*; McCavit, Timothy L. MD†,‡; Cederberg, Kevin MD§; Galindo, Rene L. MD, PhD†,∥,¶; Leavey, Patrick J. MD†,‡

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Infantile myofibromatosis (IM) is most commonly limited to cutaneous lesions that resolve spontaneously. However, generalized IM with visceral involvement, which has a reported mortality rate as high as 73%, has been successfully treated with a combination of methotrexate and vinblastine. Here we report the further efficacy of low-dose methotrexate and vinblastine in 2 pediatric patients with IM and visceral involvement and review the literature describing chemotherapy for these patients.

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.


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