Institutional members access full text with Ovid®

Share this article on:

Hydroa Vacciniforme-like Lymphoma: A Case Report From India

Boddu, Deepthi DNB; George, Renu MD; Nair, Sheila MD; Bindra, Mandeep MD; G. Mathew, Leni MD, MRCPCH

Journal of Pediatric Hematology/Oncology: May 2015 - Volume 37 - Issue 4 - p e223–e226
doi: 10.1097/MPH.0000000000000221
Online Articles: Clinical and Laboratory Observations

We report a 14-year-old Indian boy who presented with a history of weight loss, fever, facial edema, and a relapsing papulovesicular eruption on the face and limbs for 1 year. Histopathology of the skin showed dense lymphoid infiltrate from dermis to subcutaneous fat. Immunohistochemistry of this lymphoid infiltrate was CD3+, CD8+, CD56+, CD57+, Granzyme B+, TIA+, and Epstein Barr virus LMP1+. The histopathology and immunohistochemistry were consistent with the diagnosis of hydroa vacciniforme-like T-cell lymphoma. The child responded remarkably to oral steroids but relapsed on tapering doses. CHOP (Cyclophosphamide, Adriamycin, Vincristine, and Prednisolone) chemotherapy was initiated in view of systemic involvement to which he showed some response, however, the disease relapsed again. He then had a rapidly progressive disease and ultimately succumbed to his illness. This is the first case of hydroa vacciniforme-like T-cell lymphoma being reported from this subcontinent.

Department of *Pediatrics


Pathology, Christian Medical College, Vellore, India

The authors declare no conflict of interest.

Reprints: Renu George, MD, Department of Dermatology, Christian Medical College, Vellore, 632002, India (e-mails:;

Received April 7, 2014

Accepted June 21, 2014

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.