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Successful Treatment of Disseminated Adenovirus Infection in an Infant With Acute Lymphoblastic Leukemia

Alcamo, Alicia M. MD, MPH*; Pinchasik, Dawn E. MD, MS; Mo, Jun Qin MD; Grimley, Michael S. MD; O’Brien, Maureen M. MD, MS

Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0000000000000224
Online Articles: Clinical and Laboratory Observations
Abstract

Systemic adenovirus infection in the immunocompromised host is often fatal and therapeutic options are limited. We report an infant with acute lymphoblastic leukemia who developed disseminated adenovirus infection while lymphopenic during maintenance chemotherapy 6 months following a bout of adenoviral diarrhea. His serum adenoviral load peaked at 35 million copies/mL and was associated with pancytopenia and hepatic injury. Treatment with cidofovir was effective although associated with mild renal injury. The patient recovered fully and completed chemotherapy for infant acute lymphoblastic leukemia.

Author Information

Departments of *Pediatrics

Pathology

Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

The authors declare no conflict of interest.

Reprints: Maureen M. O’Brien, MD, MS, Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, MLC 7015, Cincinnati, OH 45229 (e-mail: maureen.obrien@cchmc.org).

Received March 21, 2014

Accepted June 23, 2014

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