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Diagnosis and Treatment of a Preterm Infant With Inoperable Congenital HepatoblastomaA Case Report

Miura, Yuichiro MD, PhD*; Saito, Junko MD*; Shimanuki, Yoshihisa MD, PhD; Takeyama, Junji MD, PhD; Murotsuki, Jun MD, PhD§,∥

Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0000000000000200
Online Articles: Clinical and Laboratory Observations

Reports of hepatoblastoma (HB) in preterm infants are quite rare. Herein, we report the clinical management of a preterm infant with inoperable congenital HB. A female fetus that had been diagnosed with a large liver tumor consistent with hemangioma was delivered by emergency cesarean section at 33 weeks of gestation because of fetal distress. Effective antitumor therapy could not be performed, resulting in rapid deterioration and death. The postmortem histopathologic analysis confirmed the tumor as a HB. This report demonstrates the difficulties inherent in both the image diagnosis of HB and in providing efficacious treatments for preterm infants with HB.

Author Information

Departments of *Neonatology


Clinical Pathology

§Maternal and Fetal Medicine, Miyagi Children’s Hospital

Department of Maternal and Fetal Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

The authors declare no conflict of interest.

Reprints: Yuichiro Miura, MD, PhD, School of Women’s and Infants’ Health, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia (e-mail:

Received January 19, 2014

Accepted May 8, 2014

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