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Autoimmune Neutropenia of Infancy With Recurrent Urinary Tract Infections: A Case Report

Kanai, Hiroaki MD; Sato, Hiroki MD; Takei, Yoshichika MD

Journal of Pediatric Hematology/Oncology: March 2015 - Volume 37 - Issue 2 - p e131–e134
doi: 10.1097/MPH.0000000000000205
Clinical and Laboratory Observations

Autoimmune neutropenia of infancy is characterized by minor intercurrent infections despite severe neutropenia; severe bacterial infections are uncommon. An infant developed recurrent urinary tract infections at 9 and 11 months of age. The identified uropathogens were Escherichia coli and Enterococcus faecalis, respectively. Empirical treatment with carbapenems, as broad-spectrum antibiotics, promptly resolved the infection without sequelae. Febrile neutropenic children with cancer and autoimmune neutropenia can develop urinary tract infections; therefore, in such infants, urine culture should be obtained through catheterization. In febrile neutropenic infants with no apparent fever source, cephalosporin monotherapy should not be selected empirically because Enterococci can be the involved pathogens.

Department of Pediatrics, Suwa Central Hospital, Nagano, Japan

The authors declare no conflict of interest.

Reprints: Hiroaki Kanai, MD, Department of Pediatrics, Suwa Central Hospital, Tamagawa 4300, Chino-city, Nagano 391-8503 Japan (e-mail:

Received January 10, 2014

Accepted May 13, 2014

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