Severe Anemia in an Adolescent Male With Sickle Cell Trait: A Case ReportChapa-Rodriguez, Adrian MD; Dighe, Dipti MD; Giordano, Lisa MDJournal of Pediatric Hematology/Oncology: January 2015 - Volume 37 - Issue 1 - p e60–e62 doi: 10.1097/MPH.0000000000000233 Online Articles: Clinical and Laboratory Observations Abstract Author Information Background: Sickle cell trait is generally considered a benign condition. However, it has been associated with uncommon comorbidities such as painless gross hematuria secondary to renal papillary necrosis and renal medullary carcinoma. Observation: We present a 16-year-old African American boy with sickle cell trait and a recent history of prolonged gross hematuria due to renal papillary necrosis. The patient developed severe iron deficiency anemia and required transfusion support. Conclusions: Although renal papillary necrosis is well-described, it is uncommon in pediatrics and only rarely results in the need for transfusion. Division of Pediatric Hematology/Oncology, Department of Pediatrics, John H. Stroger Jr. Hospital of Cook County, Chicago, IL The authors declare no conflict of interest. Reprints: Dipti Dighe, MD, Division of Pediatric Hematology/Oncology, Department of Pediatrics, John H. Stroger Jr. Hospital of Cook County, 1900 West Polk Street, 11th Floor, Chicago, IL 60612 (e-mail: firstname.lastname@example.org). Received December 10, 2013 Accepted June 30, 2014 Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.