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Severe Anemia in an Adolescent Male With Sickle Cell Trait: A Case Report

Chapa-Rodriguez, Adrian MD; Dighe, Dipti MD; Giordano, Lisa MD

Journal of Pediatric Hematology/Oncology: January 2015 - Volume 37 - Issue 1 - p e60–e62
doi: 10.1097/MPH.0000000000000233
Online Articles: Clinical and Laboratory Observations

Background: Sickle cell trait is generally considered a benign condition. However, it has been associated with uncommon comorbidities such as painless gross hematuria secondary to renal papillary necrosis and renal medullary carcinoma.

Observation: We present a 16-year-old African American boy with sickle cell trait and a recent history of prolonged gross hematuria due to renal papillary necrosis. The patient developed severe iron deficiency anemia and required transfusion support.

Conclusions: Although renal papillary necrosis is well-described, it is uncommon in pediatrics and only rarely results in the need for transfusion.

Division of Pediatric Hematology/Oncology, Department of Pediatrics, John H. Stroger Jr. Hospital of Cook County, Chicago, IL

The authors declare no conflict of interest.

Reprints: Dipti Dighe, MD, Division of Pediatric Hematology/Oncology, Department of Pediatrics, John H. Stroger Jr. Hospital of Cook County, 1900 West Polk Street, 11th Floor, Chicago, IL 60612 (e-mail: ddighe@cookcountyhhs.org).

Received December 10, 2013

Accepted June 30, 2014

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