Diffuse Hemorrhagic Colitis in a Patient With Dyskeratosis Congenita After Nonmyeloablative Allogeneic Hematopoietic Stem Cell TransplantationEhlert, Karoline MD; Rossig, Claudia MD; Groll, Andreas H. MD; Beyna, Torsten MD; Froehlich, Birgit MD; Juergens, Heribert MDJournal of Pediatric Hematology/Oncology: January 2015 - Volume 37 - Issue 1 - p e41–e44 doi: 10.1097/MPH.0000000000000208 Online Articles: Clinical and Laboratory Observations Abstract Author Information Dyskeratosis congenita (DC) is a rare inherited disorder characterized by reticular skin pigmentation, oral cavity leukoplakia, and nail dystrophy. Bone marrow failure in DC can only be cured by allogeneic hematopoietic stem cell transplantation (HSCT). After a nonmyeloablative, matched unrelated donor transplant, the 21-year-old patient experienced severe lower gastrointestinal tract hemorrhage caused by diffuse colitis. The etiology remained unclear. Diffuse colitis with life-threatening hemorrhage has now been reported in 3 DC patients after unrelated allogeneic HSCT. To identify the underlying causes and the disease-specific risks, and to allow for prevention and/or optimal management, data should be prospectively collected. *Department of Pediatric Hematology and Oncology, University Children’s Hospital Muenster †Department of Medicine B, University Hospital Muenster, Muenster, Germany The authors have no conflicts of interest or funding to disclose. Reprints: Karoline Ehlert, MD, Department of Pediatric Hematology and Oncology, University Medicine Greifswald, Children’s Hospital, Ferdinand-Sauerbruch-Strasse, D-17475 Greifswald, Germany (e-mail: email@example.com). Received August 8, 2013 Accepted May 20, 2014 Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.