Skip Navigation LinksHome > January 2015 - Volume 37 - Issue 1 > Diffuse Hemorrhagic Colitis in a Patient With Dyskeratosis C...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0000000000000208
Online Articles: Clinical and Laboratory Observations

Diffuse Hemorrhagic Colitis in a Patient With Dyskeratosis Congenita After Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation

Ehlert, Karoline MD*; Rossig, Claudia MD*; Groll, Andreas H. MD*; Beyna, Torsten MD; Froehlich, Birgit MD*; Juergens, Heribert MD*

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Dyskeratosis congenita (DC) is a rare inherited disorder characterized by reticular skin pigmentation, oral cavity leukoplakia, and nail dystrophy. Bone marrow failure in DC can only be cured by allogeneic hematopoietic stem cell transplantation (HSCT). After a nonmyeloablative, matched unrelated donor transplant, the 21-year-old patient experienced severe lower gastrointestinal tract hemorrhage caused by diffuse colitis. The etiology remained unclear. Diffuse colitis with life-threatening hemorrhage has now been reported in 3 DC patients after unrelated allogeneic HSCT. To identify the underlying causes and the disease-specific risks, and to allow for prevention and/or optimal management, data should be prospectively collected.

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.


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