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Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0000000000000215
Online Articles: Clinical and Laboratory Observations

Successful Hematopoietic Reconstitution by Unrelated Donor Cord Blood Transplantation in Children With Fanconi Anemia: Report of 3 Cases

Jaing, Tang-Her MD*; Chen, Shih-Hsiang MD*; Yang, Chao-Ping MD*; Hung, Iou-Jih MD*; Chang, Tsung-Yen MD*; Hsueh, Chuen MD

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Abstract

To potentially reduce late effects of malignancy and chronic graft-versus-host disease in patients with Fanconi anemia, 3 patients received unmanipulated umbilical cord blood grafts with 0 or 1 HLA antigen mismatch. The conditioning regimen consisted of fludarabine (30 mg/m2/d) for 6 days, cyclophosphamide (60 mg/kg/d) for 2 days, and rabbit antithymocyte globulin (ATG) (2.5 mg/kg/d) for 3 days. Radiation was not used in the preparative regimen. None of the patients had significant conditioning-related toxicity. All were engrafted within 10 to 19 days. All patients are well with stable or full donor chimerism after a median follow-up of 64 months (range, 13 to 69 mo).

Copyright © 2014 by Lippincott Williams & Wilkins

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