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Successful Hematopoietic Reconstitution by Unrelated Donor Cord Blood Transplantation in Children With Fanconi Anemia: Report of 3 Cases

Jaing, Tang-Her MD*; Chen, Shih-Hsiang MD*; Yang, Chao-Ping MD*; Hung, Iou-Jih MD*; Chang, Tsung-Yen MD*; Hsueh, Chuen MD

Journal of Pediatric Hematology/Oncology: November 2014 - Volume 36 - Issue 8 - p e553–e555
doi: 10.1097/MPH.0000000000000215
Online Articles: Clinical and Laboratory Observations

To potentially reduce late effects of malignancy and chronic graft-versus-host disease in patients with Fanconi anemia, 3 patients received unmanipulated umbilical cord blood grafts with 0 or 1 HLA antigen mismatch. The conditioning regimen consisted of fludarabine (30 mg/m2/d) for 6 days, cyclophosphamide (60 mg/kg/d) for 2 days, and rabbit antithymocyte globulin (ATG) (2.5 mg/kg/d) for 3 days. Radiation was not used in the preparative regimen. None of the patients had significant conditioning-related toxicity. All were engrafted within 10 to 19 days. All patients are well with stable or full donor chimerism after a median follow-up of 64 months (range, 13 to 69 mo).

*Department of Pediatrics, Division of Hematology/Oncology, Chang Gung Children’s Hospital, Chang Gung University

Department of Pathology, Chang Gung Memorial Hospital, Chang Gung University, Linkou, Taoyuan, Taiwan

Supported in part by the research grants CMRPG4A0031 and CMRPG460013 from Chang Gung Memorial Hospital.

The authors declare no conflict of interest.

Reprints: Tang-Her Jaing, MD, Department of Pediatrics, Division of Hematology and Oncology, Chang Gung Children’s Hospital, Chang Gung University, 5 Fu-Shin Street, Kwei-Shan 33305, Taoyuan, Taiwan (e-mail: jaing001@cgmh.org.tw).

Received December 26, 2013

Accepted June 19, 2014

© 2014 by Lippincott Williams & Wilkins.