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Chemotherapy-induced Alteration of SDF-1/CXCR4 Expression in Bone Marrow–derived Mesenchymal Stem Cells From Adolescents and Young Adults With Acute Lymphoblastic Leukemia

Ge, Jian PhD*; Hu, Yan MSc*; Gui, Yu MSc*; Hou, Ruiqin MSc; Yang, Mingzhen PhD*; Zeng, Qingshu MD*; Xia, Ruixiang PhD*

Journal of Pediatric Hematology/Oncology: November 2014 - Volume 36 - Issue 8 - p 617–623
doi: 10.1097/MPH.0000000000000220
Original Articles

Bone marrow–derived mesenchymal stem cells (BM-MSCs) in the marrow stroma provide a scaffold for hematopoiesis. Chemokine stromal cell–derived factor-1 (SDF-1) and its receptor CXCR4 have been shown to affect the engraftment of hematopoietic stem cells. However, little is known about SDF-1/CXCR4’s functions in regulating BM-MSCs in humans. As an initial step toward this issue, we have evaluated expression of SDF-1/CXCR4 in the BM-MSCs from a cohort of adolescents and young adults with acute lymphoblastic leukemia (ALL). We found a decrease of the CXCR4 level and an increase of the SDF-1 level in these MSCs of ALL. Moreover, cell migration appeared to be impaired in the MSCs of ALL. These changes were reversed by chemotherapy. Taken together, alteration of SDF-1/CXCR4 expression could be potentially developed as biomarkers for monitoring the effectiveness of chemotherapy.

*Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui

Department of Transfusion Medicine, Peking University People’s Hospital, Beijing, PR China

J.G. and Y.H. contributed equally.

Supported by National Natural Science Foundation of China (Grant No. 81200371), Research Fund for the Doctoral Program of Higher Education of China (Grant No. 20123420120011), and Anhui Provincial Natural Science Foundation of China (Grant No. 1208085QH154).

The authors declare no conflict of interest.

Reprints: Ruixiang Xia, PhD, Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Jixi Rd. Shushan District, Hefei, Anhui 230022, PR China (e-mail: xrx2041@163.com).

This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/3.0.

Received August 18, 2013

Accepted June 21, 2014

© 2014 by Lippincott Williams & Wilkins.