Bone marrow–derived mesenchymal stem cells (BM-MSCs) in the marrow stroma provide a scaffold for hematopoiesis. Chemokine stromal cell–derived factor-1 (SDF-1) and its receptor CXCR4 have been shown to affect the engraftment of hematopoietic stem cells. However, little is known about SDF-1/CXCR4’s functions in regulating BM-MSCs in humans. As an initial step toward this issue, we have evaluated expression of SDF-1/CXCR4 in the BM-MSCs from a cohort of adolescents and young adults with acute lymphoblastic leukemia (ALL). We found a decrease of the CXCR4 level and an increase of the SDF-1 level in these MSCs of ALL. Moreover, cell migration appeared to be impaired in the MSCs of ALL. These changes were reversed by chemotherapy. Taken together, alteration of SDF-1/CXCR4 expression could be potentially developed as biomarkers for monitoring the effectiveness of chemotherapy.
*Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui
†Department of Transfusion Medicine, Peking University People’s Hospital, Beijing, PR China
J.G. and Y.H. contributed equally.
Supported by National Natural Science Foundation of China (Grant No. 81200371), Research Fund for the Doctoral Program of Higher Education of China (Grant No. 20123420120011), and Anhui Provincial Natural Science Foundation of China (Grant No. 1208085QH154).
The authors declare no conflict of interest.
Reprints: Ruixiang Xia, PhD, Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Jixi Rd. Shushan District, Hefei, Anhui 230022, PR China (e-mail: firstname.lastname@example.org).
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Received August 18, 2013
Accepted June 21, 2014