Skip Navigation LinksHome > November 2014 - Volume 36 - Issue 8 > Chemotherapy-induced Alteration of SDF-1/CXCR4 Expression in...
Journal of Pediatric Hematology/Oncology:
doi: 10.1097/MPH.0000000000000220
Original Articles

Chemotherapy-induced Alteration of SDF-1/CXCR4 Expression in Bone Marrow–derived Mesenchymal Stem Cells From Adolescents and Young Adults With Acute Lymphoblastic Leukemia

Ge, Jian PhD*; Hu, Yan MSc*; Gui, Yu MSc*; Hou, Ruiqin MSc; Yang, Mingzhen PhD*; Zeng, Qingshu MD*; Xia, Ruixiang PhD*

Open Access
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Bone marrow–derived mesenchymal stem cells (BM-MSCs) in the marrow stroma provide a scaffold for hematopoiesis. Chemokine stromal cell–derived factor-1 (SDF-1) and its receptor CXCR4 have been shown to affect the engraftment of hematopoietic stem cells. However, little is known about SDF-1/CXCR4’s functions in regulating BM-MSCs in humans. As an initial step toward this issue, we have evaluated expression of SDF-1/CXCR4 in the BM-MSCs from a cohort of adolescents and young adults with acute lymphoblastic leukemia (ALL). We found a decrease of the CXCR4 level and an increase of the SDF-1 level in these MSCs of ALL. Moreover, cell migration appeared to be impaired in the MSCs of ALL. These changes were reversed by chemotherapy. Taken together, alteration of SDF-1/CXCR4 expression could be potentially developed as biomarkers for monitoring the effectiveness of chemotherapy.

© 2014 by Lippincott Williams & Wilkins.


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