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Bone Scintigraphy in Osteosarcoma: A Single Institution Experience

Powers, Jacquelyn M. MD*,†; Cost, Carrye MD‡,§; Cederberg, Kevin MD†,∥; Leonard, David PhD*,†; Leavey, Patrick J. MD, MB, BCh, BAO, LRCP&SI, MRCPI, DCH*,†

Journal of Pediatric Hematology/Oncology: November 2014 - Volume 36 - Issue 8 - p e543–e545
doi: 10.1097/MPH.0000000000000182
Online Articles: Clinical and Laboratory Observations

Bone scintigraphy is a well-established method to evaluate for metastatic disease in osteosarcoma. We identified a patient who had a negative (cold) bone scan at skeletal relapse and consequently reviewed the frequency of cold scans in osteosarcoma at our institution. No cold scans were identified at diagnosis, and only 1 patient had a cold scan at skeletal recurrence. No correlation was identified between clinical outcomes and bone scan features, other than identification of metastatic disease. Patients with skeletal recurrence were all symptomatic, thus we suggest that bone scintigraphy is not indicated in routine postchemotherapy surveillance for patients with osteosarcoma.

Departments of *Pediatrics

Radiology, The University of Texas Southwestern Medical Center

Children’s Medical Center, Dallas, TX

Department of Pediatrics, The University of Colorado, Denver

§Colorado Children’s Hospital, Aurora, CO

The authors declare no conflict of interest.

Reprints: Patrick J. Leavey, MD, MB, BCh, BAO, LRCP&SI, MRCPI, DCH, Division of Pediatric Hematology/Oncology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9063 (e-mail:

Received September 17, 2013

Accepted April 30, 2014

© 2014 by Lippincott Williams & Wilkins.